Chromatin plays a crucial role in genome compaction and is fundamental for regulating
multiple nuclear processes. Nucleosomes, the basic building blocks of chromatin, are …

The organization of DNA with histone proteins into chromatin is fundamental for the
regulation of gene expression. Incorporation of different histone variants into the …

A major advantage of using CRISPR/Cas9 for gene editing is multiplexing, that is, the
simultaneous targeting of many genes. However, primary transformants typically contain …

Histones serve many purposes in eukaryotic cells in the regulation of diverse genomic
processes, including transcription, replication, DNA repair, and chromatin organization. As …

Epigenetic regulations, including chromatin accessibility, nucleosome positioning and DNA
methylation intricately shape genome function. However, current chromatin profiling …

Controlled transcription of genes is critical for cell differentiation and development. Gene
expression regulation therefore involves a multilayered control from nucleosome …

The replication-dependent histone H3. 1 variant, ubiquitous in multicellular eukaryotes, has
been proposed to play key roles during chromatin replication due to its unique expression …

Human HELicase, Lymphoid Specific (HELLS), and plant homolog Deficient in DNA
Methylation 1 (DDM1), belong to a distinct class of chromatin remodelers that play important …

Histones are crucial proteins that are involved in packaging the DNA as condensed
chromatin inside the eukaryotic cell nucleus. Rather than being static packaging units, these …

Histone proteins are ubiquitous in eukaryotic cells and organize all genomic DNA into
chromatin. There are four core histone proteins, H2A, H2B, H3, and H4, and two copies of …