Transcription factors: Bridge between cell signaling and gene regulation

P Weidemüller, M Kholmatov, E Petsalaki… - …, 2021 - Wiley Online Library
Transcription factors (TFs) are key regulators of intrinsic cellular processes, such as
differentiation and development, and of the cellular response to external perturbation …

[HTML][HTML] DNA methylation: Precise modulation of chromatin structure and dynamics

S Li, Y Peng, AR Panchenko - Current opinion in structural biology, 2022 - Elsevier
DNA methylation plays a vital role in epigenetic regulation in both plants and animals, and
typically occurs at the 5-carbon position of the cytosine pyrimidine ring within the CpG …

Histone dynamics mediate DNA unwrapping and sliding in nucleosomes

GA Armeev, AS Kniazeva, GA Komarova… - Nature …, 2021 - nature.com
Nucleosomes are elementary building blocks of chromatin in eukaryotes. They tightly
wrap∼ 147 DNA base pairs around an octamer of histone proteins. How nucleosome …

Priming seeds for the future: Plant immune memory and application in crop protection

Z Yang, P Zhi, C Chang - Frontiers in Plant Science, 2022 - frontiersin.org
Plants have evolved adaptive strategies to cope with pathogen infections that seriously
threaten plant viability and crop productivity. Upon the perception of invading pathogens, the …

Binding of regulatory proteins to nucleosomes is modulated by dynamic histone tails

Y Peng, S Li, A Onufriev, D Landsman… - Nature …, 2021 - nature.com
Little is known about the roles of histone tails in modulating nucleosomal DNA accessibility
and its recognition by other macromolecules. Here we generate extensive atomic level …

Histone variant H2A. Z modulates nucleosome dynamics to promote DNA accessibility

S Li, T Wei, A Panchenko - Biophysical Journal, 2023 - cell.com
Nucleosomes containing the histone variant H2A. Z are important for gene transcription
initiation and termination, chromosome segregation and DNA double-strand break repair …

Deciphering principles of nucleosome interactions and impact of cancer-associated mutations from comprehensive interaction network analysis

W Xu, H Zhang, W Guo, L Jiang, Y Zhao… - Briefings in …, 2024 - academic.oup.com
Nucleosomes represent hubs in chromatin organization and gene regulation and interact
with a plethora of chromatin factors through different modes. In addition, alterations in …

DNA methylation cues in nucleosome geometry, stability, and unwrapping

S Li, Y Peng, D Landsman, A Panchenko - Biophysical Journal, 2022 - cell.com
2532-Pos A study on alterations in membrane physiology of human erythrocytes due to
extracellular tonicity through dielectrophoresis Jogu Sumathi, Mohd Abdul Saleem, Adeel …

Histone tail network and modulation in a nucleosome

Y Tsunaka, A Furukawa, Y Nishimura - Current Opinion in Structural …, 2022 - Elsevier
The structural unit of eukaryotic chromatin is a nucleosome, comprising two histone
H2A/H2B heterodimers and one histone (H3/H4) 2 tetramer, wrapped around by∼ 146-bp …

The pleiotropic function of human sirtuins as modulators of metabolic pathways and viral infections

MH Alqarni, AI Foudah, MM Muharram, NE Labrou - Cells, 2021 - mdpi.com
Sirtuins (SIRTs) are nicotinamide adenine dinucleotide-dependent histone deacetylases
that incorporate complex functions in the mechanisms of cell physiology. Mammals have …