Double-strand breaks (DSBs), continuously introduced into DNA by cell metabolism,
ionizing radiation and some chemicals, are the biologically most deleterious type of genome …

DNA is under constant assault from genotoxic agents which creates different kinds of DNA
damage. The precise replication of the genome and the continuous surveillance of its …

Background The histone variant histone H2A. X comprises up to 25% of the H2A
complement in mammalian cells. It is rapidly phosphorylated following exposure of cells to …

DNA double strand breaks (DSBs) are ultimate lesions for the formation of chromosomal
aberrations (CAs). The formation of CAs is dependent on many factors; some of these are …

The number of potential applications of non-thermal atmospheric pressure plasma (NTAPP)
discharges in medicine, particularly in cancer therapy, has increased in recent years …

We present a computational model for calculating the yield of radiation-induced
chromosomal aberrations in human cells based on a stochastic Monte Carlo approach and …

Background and purpose To investigate the cytogenetic damage of the intrachange type in
peripheral blood lymphocytes of patients treated for prostate cancer with different radiation …

Cellular response to DNA double-strand breaks (DSBs), the most deleterious type of DNA
damage, is highly influenced by higher-order chromatin structure in eukaryotic cells …

Exposure to DNA damaging agents triggers phosphorylation of histone variant H2AX
(generating γH2AX) in large chromatin regions flanking DNA lesions, allowing their …

To study the effects of low-and high-linear energy transfer (LET) radiation on break locations
within a chromosome, we exposed human epithelial cells in vitro to 137Cs γ rays at both low …