Activation of the Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome
drives release of the proinflammatory cytokines interleukin (IL)-1β and IL-18 and induces …

Iron is a transition metal utilized by nearly all forms of life for essential cellular processes,
such as DNA synthesis and cellular respiration. During infection by bacterial pathogens, the …

Urinary tract infections (UTIs) cause a substantial health care burden. UTIs (i) are most often
caused by uropathogenic Escherichia coli (UPEC),(ii) primarily affect otherwise healthy …

Toll-like receptor (TLR)-inducible zinc toxicity is a recently described macrophage
antimicrobial response used against bacterial pathogens. Here we investigated deployment …

Resident macrophages are abundant in the bladder, playing key roles in immunity to
uropathogens. Yet, whether they are heterogeneous, where they come from, and how they …

Uropathogenic Escherichia coli (UPEC) deploy an array of virulence factors to successfully
establish urinary tract infections. Hemolysin is a pore-forming toxin, and its expression …

The bladder supports a diversity of macrophage populations with functional roles related to
homeostasis and host defense, including clearance of cell debris from tissue, immune …

Uropathogenic Escherichia coli (UPEC) is the main etiological agent of urinary tract infection
(UTI), a widespread infectious disease of great impact on human health. This is further …

Morganella morganii is an opportunistic bacterial pathogen shown to cause a wide range of
clinical and community-acquired infections. This study was aimed at sequencing and …

Uropathogenic Escherichia coli (UPEC) is the major cause of urinary tract infections. Nearly
half of all UPEC strains secrete hemolysin, a cytotoxic pore-forming toxin. Here, we show …