Trigeminal neuralgia: An overview from pathophysiology to pharmacological treatments
The trigeminal nerve (V) is the fifth and largest of all cranial nerves, and it is responsible for
detecting sensory stimuli that arise from the craniofacial area. The nerve is divided into three …
detecting sensory stimuli that arise from the craniofacial area. The nerve is divided into three …
The neurobiology of antiepileptic drugs
MA Rogawski, W Löscher - Nature reviews neuroscience, 2004 - nature.com
Antiepileptic drugs (AEDs) provide satisfactory control of seizures for most patients with
epilepsy. The drugs have the remarkable ability to protect against seizures while permitting …
epilepsy. The drugs have the remarkable ability to protect against seizures while permitting …
Neurological perspectives on voltage-gated sodium channels
N Eijkelkamp, JE Linley, MD Baker, MS Minett, R Cregg… - Brain, 2012 - academic.oup.com
The activity of voltage-gated sodium channels has long been linked to disorders of neuronal
excitability such as epilepsy and chronic pain. Recent genetic studies have now expanded …
excitability such as epilepsy and chronic pain. Recent genetic studies have now expanded …
Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders
Voltage-gated sodium channels (VGSCs) are key mediators of intrinsic neuronal and muscle
excitability. Abnormal VGSC activity is central to the pathophysiology of epileptic seizures …
excitability. Abnormal VGSC activity is central to the pathophysiology of epileptic seizures …
[HTML][HTML] Molecular targets for antiepileptic drug development
BS Meldrum, MA Rogawski - Neurotherapeutics, 2007 - Elsevier
This review considers how recent advances in the physiology of ion channels and other
potential molecular targets, in conjunction with new information on the genetics of idiopathic …
potential molecular targets, in conjunction with new information on the genetics of idiopathic …
NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development
There is an urgent need to improve the pharmacotherapy of schizophrenia despite the
introduction of important new medications. New treatment insights may come from …
introduction of important new medications. New treatment insights may come from …
Progress report on new antiepileptic drugs: a summary of the Eigth Eilat Conference (EILAT VIII)
M Bialer, SI Johannessen, HJ Kupferberg, RH Levy… - Epilepsy research, 2007 - Elsevier
The Eigth Eilat Conference on New Antiepileptic Drugs (AEDs)-EILAT VII, took place in
Sitges, Barcelona from the 10th to 14th September, 2006. Basic scientists, clinical …
Sitges, Barcelona from the 10th to 14th September, 2006. Basic scientists, clinical …
Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites
NP Poolos, M Migliore, D Johnston - Nature neuroscience, 2002 - nature.com
The dendrites of pyramidal neurons have markedly different electrical properties from those
of the soma, owing to the non-uniform distribution of voltage-gated ion channels in …
of the soma, owing to the non-uniform distribution of voltage-gated ion channels in …
Levetiracetam: a review of its use in epilepsy
KA Lyseng-Williamson - Drugs, 2011 - Springer
Abstract Levetiracetam (Keppra®, E Keppra®) is an established second-generation anti-
epileptic drug (AED). Worldwide, levetiracetam is most commonly approved as adjunctive …
epileptic drug (AED). Worldwide, levetiracetam is most commonly approved as adjunctive …
Mechanisms of deafferentation-induced plasticity in human motor cortex
Deafferentation induces rapid plastic changes in the cerebral cortex, probably via
unmasking of pre-existent connections. Several mechanisms may contribute, such as …
unmasking of pre-existent connections. Several mechanisms may contribute, such as …