[HTML][HTML] Insulin action at a molecular level–100 years of progress
The discovery of insulin 100 years ago and its application to the treatment of human disease
in the years since have marked a major turning point in the history of medicine. The …
in the years since have marked a major turning point in the history of medicine. The …
Biochemical and cellular properties of insulin receptor signalling
RA Haeusler, TE McGraw, D Accili - Nature reviews Molecular cell …, 2018 - nature.com
The mechanism of insulin action is a central theme in biology and medicine. In addition to
the rather rare condition of insulin deficiency caused by autoimmune destruction of …
the rather rare condition of insulin deficiency caused by autoimmune destruction of …
[HTML][HTML] Energy metabolism in the liver
L Rui - Comprehensive physiology, 2014 - ncbi.nlm.nih.gov
The liver is an essential metabolic organ, and its metabolic activity is tightly controlled by
insulin and other metabolic hormones. Glucose is metabolized into pyruvate through …
insulin and other metabolic hormones. Glucose is metabolized into pyruvate through …
[HTML][HTML] Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models to disease mechanisms
S Guo - The Journal of endocrinology, 2014 - ncbi.nlm.nih.gov
Insulin resistance is a major underlying mechanism for the “metabolic syndrome”, which is
also known as insulin resistance syndrome. Metabolic syndrome is increasing at an …
also known as insulin resistance syndrome. Metabolic syndrome is increasing at an …
[HTML][HTML] Mitochondrial dysfunction and insulin resistance: an update
MK Montgomery, N Turner - Endocrine connections, 2015 - ec.bioscientifica.com
Mitochondrial dysfunction has been implicated in the development of insulin resistance (IR);
however, a large variety of association and intervention studies as well as genetic …
however, a large variety of association and intervention studies as well as genetic …
[HTML][HTML] Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training
CK Roberts, AL Hevener, RJ Barnard - Comprehensive physiology, 2013 - ncbi.nlm.nih.gov
Metabolic syndrome (MS) is a collection of cardiometabolic risk factors that includes obesity,
insulin resistance, hypertension, and dyslipidemia. Although there has been significant …
insulin resistance, hypertension, and dyslipidemia. Although there has been significant …
Estrogen improves insulin sensitivity and suppresses gluconeogenesis via the transcription factor Foxo1
Premenopausal women exhibit enhanced insulin sensitivity and reduced incidence of type 2
diabetes (T2D) compared with age-matched men, but this advantage disappears after …
diabetes (T2D) compared with age-matched men, but this advantage disappears after …
Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis
J Miao, AV Ling, PV Manthena, ME Gearing… - Nature …, 2015 - nature.com
Despite the well-documented association between insulin resistance and cardiovascular
disease, the key targets of insulin relevant to the development of cardiovascular disease are …
disease, the key targets of insulin relevant to the development of cardiovascular disease are …
The association between type 2 diabetes mellitus and Parkinson's disease
JLY Cheong, E de Pablo-Fernandez… - Journal of …, 2020 - content.iospress.com
In recent years, an emerging body of evidence has forged links between Parkinson's
disease (PD) and type 2 diabetes mellitus (T2DM). In observational studies, those with …
disease (PD) and type 2 diabetes mellitus (T2DM). In observational studies, those with …
Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance
SH Choi, HN Ginsberg - Trends in Endocrinology & Metabolism, 2011 - cell.com
Insulin resistance (IR) affects not only the regulation of carbohydrate metabolism but all
aspects of lipid and lipoprotein metabolism. IR is associated with increased secretion of …
aspects of lipid and lipoprotein metabolism. IR is associated with increased secretion of …