Colorectal cancer (CRC) is a heterogeneous disease, including at least three major forms:
hereditary, sporadic and colitis-associated CRC. A large body of evidence indicates that …

Patients with inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease,
are at increased risk of developing colon cancer, confirming that chronic inflammation …

Background & Aims Alterations in the intestinal microbiota affect development of colorectal
cancer and drug metabolism. We studied whether the intestinal microbiota affect the ability …

Colorectal cancer (CRC) is the one of the leading causes of cancer-related deaths in the
world. CRC is responsible for more than 600,000 deaths annually and incidence rates are …

Abstract Hydrogen sulfide (H2S), a metabolic end product of sulfate‐reducing bacteria,
represents a genotoxic insult to the colonic epithelium, which may also be linked with …

Compelling experimental and clinical evidence supports the notion that cyclooxygenase-2,
the inducible isoform of cyclooxygenase, plays a crucial role in oncogenesis. Clinical and …

Accumulating evidence has indicated that inflammatory responses are important for cancer
development. Epidemiological studies have shown that regular use of non-steroidal anti …

Abstract Cyclooxygenase 2 (COX2) is overexpressed in 80% of colon adenocarcinomas.
However, the mechanism leading to aberrant COX2 expression in tumors is unclear …

Chemopreventive effects and associated mechanisms of withaferin A (WA) against intestinal
and colon carcinogenesis remain unknown. We investigated the chemopreventive effect of …

Background & Aims Diet contributes to colorectal cancer development and may be
potentially modified. We wanted to identify the biological mechanisms underlying colorectal …