Elastic fibers are an important component of the extracellular matrix, providing stretch,
resilience, and cell interactivity to a broad range of elastic tissues. Elastin makes up the …

Marfan syndrome (MFS), a relatively common autosomal dominant hereditary disorder of
connective tissue with prominent manifestations in the skeletal, ocular, and cardiovascular …

Nuclear orphan receptor Nur77 has important roles in many biological processes. However,
a physiological ligand for Nur77 has not been identified. Here, we report that the octaketide …

Syndecans are type I transmembrane proteins having a core protein modified with
glycosaminoglycan chains, most commonly heparan sulphate. They are an ancient group of …

Elastic fibres are insoluble components of the extracellular matrix of dynamic connective
tissues such as skin, arteries, lungs and ligaments. They are laid down during development …

The coacervation of tropoelastin represents the first major stage of elastic fiber assembly.
The process has been modeled in vitro by numerous studies, initially with mixtures of …

We have discovered that fibrillin-1, which forms extracellular microfibrils, can regulate the
bioavailability of transforming growth factor (TGF) β1, a powerful cytokine that modulates cell …

Cell migration during vascular remodelling is regulated by crosstalk between growth factor
receptors and integrin receptors, which together coordinate cytoskeletal and motogenic …

Elastic fibres are a major class of extracellular matrix fibres that are abundant in dynamic
connective tissues such as arteries, lungs, skin and ligaments. Their structural role is to …

STUDY QUESTION How do elastic matrisome components change during the lifetime of the
human ovary? SUMMARY ANSWER The deposition and remodeling of mechanical …