Emerging connections between cerebellar development, behaviour and complex brain disorders

A Sathyanesan, J Zhou, J Scafidi, DH Heck… - Nature Reviews …, 2019 - nature.com
The human cerebellum has a protracted developmental timeline compared with the
neocortex, expanding the window of vulnerability to neurological disorders. As the …

Consensus paper: experimental neurostimulation of the cerebellum

LN Miterko, KB Baker, J Beckinghausen, LV Bradnam… - The Cerebellum, 2019 - Springer
The cerebellum is best known for its role in controlling motor behaviors. However, recent
work supports the view that it also influences non-motor behaviors. The contribution of the …

Cerebellar deep brain stimulation for chronic post-stroke motor rehabilitation: a phase I trial

KB Baker, EB Plow, S Nagel, AB Rosenfeldt… - Nature medicine, 2023 - nature.com
Upper-extremity impairment after stroke remains a major therapeutic challenge and a target
of neuromodulation treatment efforts. In this open-label, non-randomized phase I trial, we …

[图书][B] Broken movement: the neurobiology of motor recovery after stroke

JW Krakauer, ST Carmichael - 2022 - books.google.com
An account of the neurobiology of motor recovery in the arm and hand after stroke by two
experts in the field. Stroke is a leading cause of disability in adults and recovery is often …

Cerebellum lecture: the cerebellar nuclei—core of the cerebellum

JM Kebschull, F Casoni, GG Consalez, D Goldowitz… - The Cerebellum, 2024 - Springer
The cerebellum is a key player in many brain functions and a major topic of neuroscience
research. However, the cerebellar nuclei (CN), the main output structures of the cerebellum …

Neuromodulation of the cerebellum rescues movement in a mouse model of ataxia

LN Miterko, T Lin, J Zhou, ME van der Heijden… - Nature …, 2021 - nature.com
Deep brain stimulation (DBS) relieves motor dysfunction in Parkinson's disease, and other
movement disorders. Here, we demonstrate the potential benefits of DBS in a model of …

Subthalamic nucleus deep brain stimulation: basic concepts and novel perspectives

C Hamani, G Florence, H Heinsen, BR Plantinga… - eneuro, 2017 - eneuro.org
Over the last decades, extensive basic and clinical knowledge has been acquired on the
use of subthalamic nucleus (STN) deep brain stimulation (DBS) for Parkinson's disease …

Purkinje cell misfiring generates high-amplitude action tremors that are corrected by cerebellar deep brain stimulation

AM Brown, JJ White, ME van der Heijden, J Zhou, T Lin… - Elife, 2020 - elifesciences.org
Tremor is currently ranked as the most common movement disorder. The brain regions and
neural signals that initiate the debilitating shakiness of different body parts remain unclear …

Low-frequency stimulation enhances ensemble co-firing and dexterity after stroke

P Khanna, D Totten, L Novik, J Roberts, RJ Morecraft… - Cell, 2021 - cell.com
Electrical stimulation is a promising tool for modulating brain networks. However, it is
unclear how stimulation interacts with neural patterns underlying behavior. Specifically, how …

Functional brain network features specify DBS outcome for patients with treatment resistant depression

AH Ghaderi, EC Brown, DL Clark, R Ramasubbu… - Molecular …, 2023 - nature.com
Deep brain stimulation (DBS) has shown therapeutic benefits for treatment resistant
depression (TRD). Stimulation of the subcallosal cingulate gyrus (SCG) aims to alter …