Protein kinase C (PKC) isozymes belong to a family of Ser/Thr kinases whose activity is
governed by reversible release of an autoinhibitory pseudosubstrate. For conventional and …

Over the course of natural history, countless animal species have evolved adaptive
behavioral systems to cope with dangerous situations and promote survival. Emotional …

Chromatin modifications, especially histone-tail acetylation, have been implicated in
memory formation. Increased histone-tail acetylation induced by inhibitors of histone …

The ability to store and later use information is essential for a variety of adaptive behaviors,
including integration, learning, generalization, prediction and inference. In this Review, we …

Analogous to learning and memory storage, long-term potentiation (LTP) is divided into
induction and maintenance phases. Testing the hypothesis that the mechanism of LTP …

Activity-dependent changes in the strength of excitatory synapses are a cellular mechanism
for the plasticity of neuronal networks that is widely recognized to underlie cognitive …

In the adult mammalian brain, more than 250 protein kinases are expressed, but only a few
of these kinases are currently known to enable learning and memory. Based on this …

Synaptic plasticity is a key mechanism for chronic pain. It occurs at different levels of the
central nervous system, including spinal cord and cortex. Studies have mainly focused on …

Most of the molecular mechanisms contributing to long-term memory have been found to
consolidate information within a brief time window after learning, but not to maintain …

Abstract Long-term potentiation (LTP), a well-characterized form of synaptic plasticity, has
long been postulated as a cellular correlate of learning and memory. Although LTP can …