El desarrollo cerebral es un proceso altamente regulado y dinámico. Requiere la expresión
de distintos genes que interactúan de forma coordinada y sinérgica. Esta necesidad de …

SWI/SNF protein complexes are evolutionarily conserved epigenetic regulators described in
all eukaryotes. In metameric animals, the complexes are involved in all processes occurring …

Heterozygous variants in bromodomain and plant homeodomain containing transcription
factor (BPTF) cause the neurodevelopmental disorder with dysmorphic facies and distal limb …

Mutually linked expression and methylation dynamics in the brain govern genome
regulation over the whole lifetime with an impact on cognition, psychological disorders, and …

Neurogenesis begins with neural stem cells undergoing symmetric proliferative divisions to
expand and then switching to asymmetric differentiative divisions to generate neurons in the …

Copy-number variants (CNVs) are genome-wide structural variations involving the
duplication or deletion of large nucleotide sequences. While these types of variations can be …

Throughout our entire life, our brain is constantly shaped by the experience of both the outer
and the inner environments. Sensory perceptions, as well as thoughts and feelings, are …

Bipolar disorder (BD) is a severe mental illness that can result from neurodevelopmental
aberrations, particularly in familial BD, which may include causative genetic variants. In the …

Pathogenic variants in ATP-dependent chromatin remodeling proteins are a recurrent cause
of neurodevelopmental disorders (NDDs). The NURF complex consists of BPTF and either …

During late embryonic development of the cerebral cortex, the major class of cortical output
neurons termed subcerebral projection neurons (SCPN; including the predominant …