Background Amoxicillin has been in use since the 1970s; it is the most widely used penicillin
both alone and in combination with the β-lactamase clavulanic acid. Objectives In this …

Purpose Augmented renal clearance (ARC) is common in critically ill patients and may lead
to subtherapeutic levels of antibiotics, thus influencing clinical outcomes and emergence of …

Purpose Risk factors for β-lactam antibiotic underdosing in critically ill patients have not
been described in large-scale studies. The objective of this study was to describe …

There is little data available to guide amoxicillin-clavulanic acid dosing in critically ill
children. The primary objective of this study was to investigate the pharmacokinetics of both …

Antimicrobial dosing in the intensive care unit (ICU) can be problematic due to various
challenges including unique physiological changes observed in critically ill patients and the …

In some patient groups, including critically ill patients, the pharmacokinetics of β-lactam
antibiotics may be profoundly disturbed due to pathophysiological changes in distribution …

Background This study aimed to evaluate the oral switch (OS) stewardship intervention in
the intensive care unit (ICU). Methods This was a retrospective study with a convenience …

This study describes the population pharmacokinetics of fosfomycin in critically ill patients. In
this observational study, serial blood samples were taken over several dosing intervals of …

ABSTRACT A simple and rapid ultra-high-performance liquid chromatography (UHPLC)
method using UV detection was developed for the simultaneous determination of eight β …

Background Augmented renal clearance (ARC) is recognized as a leading cause of β-
lactam subexposure when conventional dosing regimens are used. The main objective was …