In addition to its structural role, the skeleton serves as an endocrine organ that controls
mineral metabolism and energy homeostasis. Three major cell types in bone-osteoblasts …

Osteoporosis is characterized by reduced bone mass and disruption of bone architecture,
resulting in increased risk of fragility fractures and significant long-term disability. Although …

Bone regulates its mass and quality in response to diverse mechanical, hormonal, and local
signals. The bone anabolic or catabolic responses to these signals are often received by …

Sclerostin, a protein secreted from osteocytes, negatively regulates the WNT signaling
pathway by binding to the LRP5/6 co-receptors and further inhibits bone formation and …

X-linked hypophosphatemia (XLH) is the most common genetic form of hypophosphatemic
rickets and osteomalacia. In this disease, mutations in the PHEX gene lead to elevated …

Since phosphorus is a component of hydroxyapatite, its prolonged deprivation affects bone
mineralization. Fibroblast growth factor 23 (FGF23) is essential for maintaining phosphate …

Objective An increased prevalence of vertebral fractures (VFs) has been reported in
previous studies. The aim of this study was to evaluate the association between bone …

Bone has long been considered as a silent organ that provides a reservoir of calcium and
phosphorus, traditionally. Recently, further study of bone has revealed additional functions …

As the most numerous and long-lived of all bone cells, osteocytes have essential functions
in regulating skeletal health. Through the lacunar-canalicular system, secreted proteins from …

X-linked hypophosphatemia (XLH) is caused by a loss-of-function mutation in the phosphate
regulating gene with homology to endopeptidase located on the X chromosome (PHEX) …