[HTML][HTML] Review of the Geant4-DNA simulation toolkit for radiobiological applications at the cellular and DNA level
Simple Summary A brief description of the methodologies to simulate ionizing radiation
transport in biologically relevant matter is presented. Emphasis is given to the physical …
transport in biologically relevant matter is presented. Emphasis is given to the physical …
Simulation of DNA damage using Geant4‐DNA: an overview of the “molecularDNA” example application
KP Chatzipapas, NH Tran, M Dordevic… - Precision Radiation …, 2023 - Wiley Online Library
Purpose The scientific community shows great interest in the study of DNA damage
induction, DNA damage repair, and the biological effects on cells and cellular systems after …
induction, DNA damage repair, and the biological effects on cells and cellular systems after …
[HTML][HTML] Radical production with pulsed beams: understanding the transition to FLASH
A Espinosa-Rodriguez, D Sanchez-Parcerisa… - International Journal of …, 2022 - mdpi.com
Ultra-high dose rate (UHDR) irradiation regimes have the potential to spare normal tissue
while keeping equivalent tumoricidal capacity than conventional dose rate radiotherapy …
while keeping equivalent tumoricidal capacity than conventional dose rate radiotherapy …
TOPAS-nBio validation for simulating water radiolysis and DNA damage under low-LET irradiation
J Ramos-Méndez, JA LaVerne… - Physics in Medicine …, 2021 - iopscience.iop.org
The chemical stage of the Monte Carlo track-structure simulation code Geant4-DNA has
been revised and validated. The root-mean-square (RMS) empirical parameter that dictates …
been revised and validated. The root-mean-square (RMS) empirical parameter that dictates …
[HTML][HTML] A Geant4-DNA evaluation of radiation-induced DNA damage on a human fibroblast
Simple Summary DNA damage caused by ionizing radiation in a human fibroblast cell
evaluated by the Geant4-DNA Monte Carlo toolkit is presented. A validation study using a …
evaluated by the Geant4-DNA Monte Carlo toolkit is presented. A validation study using a …
[HTML][HTML] Initial yield of hydrated electron production from water radiolysis based on first-principles calculation
T Kai, T Toigawa, Y Matsuya, Y Hirata, T Tezuka… - RSC …, 2023 - pubs.rsc.org
Many scientific insights into water radiolysis have been applied for developing life science,
including radiation-induced phenomena, such as DNA damage and mutation induction or …
including radiation-induced phenomena, such as DNA damage and mutation induction or …
[HTML][HTML] First-principles simulation of an ejected electron produced by monochromatic deposition energy to water at the femtosecond order
T Kai, T Toigawa, Y Matsuya, Y Hirata, T Tezuka… - RSC …, 2023 - pubs.rsc.org
This study uses a time-dependent first-principles simulation code to investigate the transient
dynamics of an ejected electron produced in the monochromatic deposition energy from 11 …
dynamics of an ejected electron produced in the monochromatic deposition energy from 11 …
TOPAS-nBio simulation of temperature-dependent indirect DNA strand break yields
J Ramos-Méndez, O García-García… - Physics in Medicine …, 2022 - iopscience.iop.org
Abstract Current Monte Carlo simulations of DNA damage have been reported only at
ambient temperature. The aim of this work is to use TOPAS-nBio to simulate the yields of …
ambient temperature. The aim of this work is to use TOPAS-nBio to simulate the yields of …
[HTML][HTML] The general-purpose Geant4 Monte Carlo toolkit and its Geant4-DNA extension to investigate mechanisms underlying the FLASH effect in radiotherapy …
FLASH radiotherapy is a promising approach to cancer treatment that offers several
advantages over conventional radiotherapy. With this novel technique, high doses of …
advantages over conventional radiotherapy. With this novel technique, high doses of …
[HTML][HTML] In-silico calculations of DNA damage induced by α-particles in the 224Ra DaRT decay chain for a better understanding of the radiobiological effectiveness of …
L Ballisat, L Beck, C De Sio, S Guatelli, D Sakata… - Physica Medica, 2023 - Elsevier
Diffusing alpha-emitters radiation Therapy (DaRT) is an interstitial brachytherapy technique
using 224 Ra seeds. For accurate treatment planning a good understanding of the early …
using 224 Ra seeds. For accurate treatment planning a good understanding of the early …