A comprehensive metabolic map for production of bio-based chemicals

SY Lee, HU Kim, TU Chae, JS Cho, JW Kim, JH Shin… - Nature …, 2019 - nature.com
Production of industrial chemicals using renewable biomass feedstock is becoming
increasingly important to address limited fossil resources, climate change and other …

Organic acids as antimicrobial food agents: applications and microbial productions

HB Coban - Bioprocess and Biosystems Engineering, 2020 - Springer
Food safety is a global health and socioeconomic concern since many people still suffer
from various acute and life-long diseases, which are caused by consumption of unsafe food …

Recent advances and perspectives on production of value-added organic acids through metabolic engineering

H Liu, Y Jin, R Zhang, Y Ning, Y Yu, P Xu, L Deng… - Biotechnology …, 2023 - Elsevier
Organic acids are important consumable materials with a wide range of applications in the
food, biopolymer and chemical industries. The global consumer organic acids market is …

Harnessing yeast organelles for metabolic engineering

SK Hammer, JL Avalos - Nature chemical biology, 2017 - nature.com
Each subcellular compartment in yeast offers a unique physiochemical environment and
metabolite, enzyme, and cofactor composition. While yeast metabolic engineering has …

Metabolic engineering in the biotechnological production of organic acids in the tricarboxylic acid cycle of microorganisms: advances and prospects

X Yin, J Li, H Shin, G Du, L Liu, J Chen - Biotechnology advances, 2015 - Elsevier
Organic acids, which are chemically synthesized, are also natural intermediates in the
metabolic pathways of microorganisms, among which the tricarboxylic acid (TCA) cycle is …

Key technologies for the industrial production of fumaric acid by fermentation

Q Xu, S Li, H Huang, J Wen - Biotechnology advances, 2012 - Elsevier
The growing concern about the safety of food and dairy additives and the increasing costs of
petroleum-based chemicals have rekindled the interest in the fermentation processes for …

Construction of reductive pathway in Saccharomyces cerevisiae for effective succinic acid fermentation at low pH value

D Yan, C Wang, J Zhou, Y Liu, M Yang, J Xing - Bioresource technology, 2014 - Elsevier
Succinic acid is an important precursor for the synthesis of high-value-added products.
Saccharomyces cerevisiae is a suitable platform for succinic acid production because of its …

Metabolic engineering of Escherichia coli for the production of fumaric acid

CW Song, DI Kim, S Choi, JW Jang… - Biotechnology and …, 2013 - Wiley Online Library
Fumaric acid is a naturally occurring organic acid that is an intermediate of the tricarboxylic
acid cycle. Fungal species belonging to Rhizopus have traditionally been employed for the …

Synthesis of chemicals by metabolic engineering of microbes

X Sun, X Shen, R Jain, Y Lin, J Wang, J Sun… - Chemical society …, 2015 - pubs.rsc.org
Metabolic engineering is a powerful tool for the sustainable production of chemicals. Over
the years, the exploration of microbial, animal and plant metabolism has generated a wealth …

Metabolic engineering and fermentation optimization strategies for producing organic acids of the tricarboxylic acid cycle by microbial cell factories

S Zhou, N Ding, R Han, Y Deng - Bioresource Technology, 2023 - Elsevier
The organic acids of the tricarboxylic acid (TCA) pathway are important platform compounds
and are widely used in many areas. The high-productivity strains and high-efficient and low …