Cyclins, cyclin-dependent kinases and other components of the core cell cycle machinery
drive cell division. Growing evidence indicates that this machinery operates in a distinct …

Background Individuals affected with autism often suffer additional co-morbidities such as
intellectual disability. The genes contributing to autism cluster on a relatively limited number …

Poised enhancers (PEs) represent a genetically distinct set of distal regulatory elements that
control the expression of major developmental genes. Before becoming activated in …

Chromatin domains and loops are important elements of chromatin structure and dynamics,
but much remains to be learned about their exact biological role and nature. Topological …

The human brain is a complex organ comprised of distinct cell types, and the contribution of
the 3D genome to lineage specific gene expression remains poorly understood. To decipher …

The dynamic changes in the epigenome resulting from the intricate interactions of genetic
and environmental factors play crucial roles in individual growth and development …

Chromatin is organized into multiscale three-dimensional structures, including chromosome
territories, A/B compartments, topologically associating domains, and chromatin loops. This …

Cerebral arachnoid cysts (ACs) are one of the most common and poorly understood types of
developmental brain lesion. To begin to elucidate AC pathogenesis, we performed an …

Since the beautiful images of Santiago Ramón y Cajal provided a first glimpse into the
immense diversity and complexity of cell types found in the cerebral cortex, neuroscience …

Neurons are remarkably long-lived, non-dividing cells that must maintain their functional
features (eg, electrical properties, chemical signaling) for extended periods of time–decades …