Cystic fibrosis (CF) is a genetic disease with mutational changes leading to profound
dysbiosis, both pulmonary and intestinal, from a very young age. This dysbiosis plays an …

Cystic fibrosis (CF) is the most common lethal, multisystemic genetic disorder in Caucasians.
Mutations in the gene encoding the cystic fibrosis transmembrane regulator (CFTR) protein …

Microbial diversity in the cystic fibrosis (CF) lung decreases over decades as pathogenic
bacteria such as Pseudomonas aeruginosa take over. The dynamics of the CF microbiome …

Pseudomonas aeruginosa is a nosocomial pathogen with a prevalence in
immunocompromised individuals and is particularly abundant in the lung microbiome of …

At its current rate, the rise of antimicrobial-resistant (AMR) infections is predicted to paralyze
our industries and healthcare facilities while becoming the leading global cause of loss of …

Cystic fibrosis (CF) is a hereditary disease caused by mutations in the CF transmembrane
conductance regulator (CFTR) gene, triggering dysfunction of the anion channel in several …

Ecological networking and in vitro studies predict that anaerobic, mucus-degrading bacteria
are keystone species in cystic fibrosis (CF) microbiomes. The metabolic byproducts from …

Viral-bacterial coinfections of the respiratory tract have long been associated with worsened
disease outcomes. Clinical and basic research studies demonstrate that these infections are …

The respiratory tract of individuals with cystic fibrosis is host to polymicrobial infections that
persist for decades and lead to significant morbidity and mortality. Improving our …

Despite being considered the simplest form of life, bacteria remain enigmatic, particularly in
light of pathogenesis and evolving antimicrobial resistance. After three decades of …