High-risk human papillomaviruses (HPVs) cause essentially all cervical cancers, most anal
and oropharyngeal cancers, and some vaginal, vulvar, and penile cancers. Improved …

Head and neck cancers (HNCs) are a highly heterogeneous group of tumours that are
associated with diverse clinical outcomes. Recent evidence has demonstrated that human …

Previous studies have established that a subset of head and neck tumors contains human
papillomavirus (HPV) sequences and that HPV-driven head and neck cancers display …

Human papillomaviruses (HPVs) are ubiquitous, well adapted to their host and cleverly
sequestered away from immune responses. HPV infections can be productive, subclinical or …

APOBEC3B cytosine deaminase activity has recently emerged as a significant mutagenic
factor in human cancer. APOBEC activity is induced in virally infected cells, and APOBEC …

Background Concurrent chemoradiotherapy (CCRT) is the standard treatment for patients
with unresectable, nonmetastatic locoregionally advanced squamous-cell carcinoma of the …

Squamous cell carcinomas (SCCs) are one of the most frequent forms of human
malignancy, but, other than TP53 mutations, few causative somatic aberrations have been …

Understanding of oropharyngeal squamous cell carcinoma has significantly progressed
over the last decades, and the concept that this disease can be subdivided into two distinct …

Purpose In squamous cell carcinomas of the head and neck (HNSCC), the increasing
incidence of oropharyngeal squamous cell carcinomas (OPSCCs) is attributable to human …

Persistent infection with carcinogenic human papillomaviruses (HPV) causes the majority of
anogenital cancers and a subset of head and neck cancers. The HPV genome is frequently …