Breast cancer is a major public health problem worldwide. Management of breast cancer
was last reviewed in the Journal in 1992.1 The accumulation of new biologic information, the …

A systematic review of chemotherapy trials in several tumour types was performed by The
Swedish Council of Technology Assessment in Health Care (SBU). The procedures for the …

CDC, the Infectious Diseases Society of America, and the American Society of Blood and
Marrow Transplantation have cosponsored these guidelines for preventing opportunistic …

Background High-dose chemotherapy (HDC) has been widely utilized in high-risk breast
cancer, but it may induce cardiac toxicity. Cardiac dysfunction may become evident weeks or …

We determined the safety, immune activating effects, and potential efficacy of iv infusion of
ex vivo interleukin-2 (IL-2) activated natural killer (NK) cells (part I) or IL-2 boluses (part II) …

Background We conducted a randomized trial in which we compared high-dose
chemotherapy plus hematopoietic stem-cell rescue with a prolonged course of monthly …

PURPOSE: Previous studies have shown that bone metastases are revealed by magnetic
resonance imaging (MRI) or bone marrow scintigraphy several months before they are …

Treatment of advanced breast cancer with autologous stem cell transplantation is limited by
a high probability of disease relapse. In clinical trials, interleukin 2 (IL-2) alone can expand …

BACKGROUND: Uncontrolled studies have reported encouraging outcomes for patients with
high-risk primary breast cancer treated with high-dose chemotherapy and autologous …

Our objective was to determine whether an immune response can be generated against
MUC1 peptide and against tumor cell MUC1 after vaccination with MUC1-keyhole limpet …