The role of osteoblasts in energy homeostasis

N Dirckx, MC Moorer, TL Clemens… - Nature Reviews …, 2019 - nature.com
Osteoblasts are specialized mesenchymal cells that synthesize bone matrix and coordinate
the mineralization of the skeleton. These cells work in harmony with osteoclasts, which …

Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication

JB Funcke, PE Scherer - Journal of lipid research, 2019 - ASBMB
The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

Lipocalin-2: a master mediator of intestinal and metabolic inflammation

AR Moschen, TE Adolph, RR Gerner, V Wieser… - Trends in Endocrinology …, 2017 - cell.com
Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is
released by various cell types and is an attractive biomarker of inflammation, ischemia …

Endocrine role of bone in the regulation of energy metabolism

R Zhou, Q Guo, Y Xiao, Q Guo, Y Huang, C Li, X Luo - Bone research, 2021 - nature.com
Abstracts Bone mainly functions as a supportive framework for the whole body and is the
major regulator of calcium homeostasis and hematopoietic function. Recently, an increasing …

Revisiting the adipocyte: a model for integration of cytokine signaling in the regulation of energy metabolism

A Rodríguez, S Ezquerro… - American Journal …, 2015 - journals.physiology.org
Adipose tissue constitutes an extremely active endocrine organ with a network of signaling
pathways enabling the organism to adapt to a wide range of different metabolic challenges …

The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases

V Abella, M Scotece, J Conde, R Gómez, A Lois… - Biomarkers, 2015 - Taylor & Francis
Abstract Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin
(NGAL), is a secreted glycoprotein that belongs to a group of transporters of small lipophilic …

Adipose tissue-derived signatures for obesity and type 2 diabetes: adipokines, batokines and microRNAs

MW Lee, M Lee, KJ Oh - Journal of clinical medicine, 2019 - mdpi.com
Obesity is one of the main risk factors for type 2 diabetes mellitus (T2DM). It is closely related
to metabolic disturbances in the adipose tissue that primarily functions as a fat reservoir. For …

PPARγ signaling and emerging opportunities for improved therapeutics

S Wang, EJ Dougherty, RL Danner - Pharmacological Research, 2016 - Elsevier
Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated nuclear
receptor that regulates glucose and lipid metabolism, endothelial function and inflammation …

Thermogenic capacity is antagonistically regulated in classical brown and white subcutaneous fat depots by high fat diet and endurance training in rats: impact on …

MV Wu, G Bikopoulos, S Hung, RB Ceddia - Journal of Biological Chemistry, 2014 - ASBMB
This study investigated the regulation of thermogenic capacity in classical brown adipose
tissue (BAT) and subcutaneous inguinal (SC Ing) white adipose tissue (WAT) and how it …

Adipokines from white adipose tissue in regulation of whole body energy homeostasis

B Sahu, NC Bal - Biochimie, 2023 - Elsevier
Diseases originating from altered energy homeostasis including obesity, and type 2
diabetes are rapidly increasing worldwide. Research in the last few decades on animal …