The peripheral autonomic nervous system (ANS) is known to regulate gene expression in
primary tumours and their surrounding microenvironment. Activation of the sympathetic …

Renin-angiotensin system (RAS) inhibitors (RASi)—widely prescribed for the treatment of
cardiovascular diseases—have considerable potential in oncology. The RAS plays a crucial …

Chronic stress results in disturbances of body hormones through the neuroendocrine
system. Cancer patients often experience recurrent anxiety and restlessness during disease …

Introduction Several anti-hypertensive drugs have photosensitizing properties, however it
remains unclear whether long-term users of these drugs are also at increased risk of skin …

A high intratumoral nerve density is correlated with poor survival, high metastasis, and high
recurrence across multiple solid tumor types. Recent research has revealed that cancer cells …

The pharmacological class of β-blockers includes a plea of molecules with largely different
pharmacokinetic and pharmacodynamic characteristics with a protective effect that may …

Background The biological perturbation associated with psychological and surgical stress is
implicated in cancer recurrence. Preclinical evidence suggests that beta-blockers can be …

Background Beta-blockers are antihypertensive drugs and have shown potential in cancer
prognosis. However, this benefit has not been well defined due to inconsistent results from …

Background β-adrenergic receptors are upregulated in melanoma cells and contribute to an
immunosuppressive, pro-tumorigenic microenvironment. This study investigated the …

Cancer metastasis and treatment resistance are the main causes of treatment failure and
cancer-related deaths. Their underlying mechanisms remain to be fully elucidated and have …