TGF-β in hepatic stellate cell activation and liver fibrogenesis—updated 2019
Liver fibrosis is an advanced liver disease condition, which could progress to cirrhosis and
hepatocellular carcinoma. To date, there is no direct approved antifibrotic therapy, and …
hepatocellular carcinoma. To date, there is no direct approved antifibrotic therapy, and …
Liver regeneration and inflammation: from fundamental science to clinical applications
Liver regeneration is a complex process involving the crosstalk of multiple cell types,
including hepatocytes, hepatic stellate cells, endothelial cells and inflammatory cells. The …
including hepatocytes, hepatic stellate cells, endothelial cells and inflammatory cells. The …
Cancer nanotechnology: current status and perspectives
JA Kemp, YJ Kwon - Nano convergence, 2021 - Springer
Modern medicine has been waging a war on cancer for nearly a century with no tangible
end in sight. Cancer treatments have significantly progressed, but the need to increase …
end in sight. Cancer treatments have significantly progressed, but the need to increase …
[HTML][HTML] Medicinal uses, pharmacological activities, phytochemistry, and the molecular mechanisms of Punica granatum L.(pomegranate) plant extracts: A review
N Maphetu, JO Unuofin, NP Masuku, C Olisah… - Biomedicine & …, 2022 - Elsevier
Punica granatum L (pomegranate) is one of the Mediterranean medicinal plants that has
been used for generations in treating ulcers, diarrhea, and male infertility. Increasing …
been used for generations in treating ulcers, diarrhea, and male infertility. Increasing …
Transforming growth factor-β signaling: from tissue fibrosis to therapeutic opportunities
LL Ren, XJ Li, TT Duan, ZH Li, JZ Yang… - Chemico-biological …, 2023 - Elsevier
Fibrosis refers to the excessive deposition of extracellular matrix components in the
processes of wound repair or tissue regeneration after tissue damage. Fibrosis occurs in …
processes of wound repair or tissue regeneration after tissue damage. Fibrosis occurs in …
Friend or foe? The elusive role of hepatic stellate cells in liver cancer
B Cogliati, CN Yashaswini, S Wang, D Sia… - Nature Reviews …, 2023 - nature.com
Liver fibrosis is a substantial risk factor for the development and progression of liver cancer,
which includes hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma …
which includes hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma …
Necroptosis contributes to chronic inflammation and fibrosis in aging liver
S Mohammed, N Thadathil, R Selvarani, EH Nicklas… - Aging cell, 2021 - Wiley Online Library
Inflammaging, characterized by an increase in low‐grade chronic inflammation with age, is a
hallmark of aging and is strongly associated with various age‐related diseases, including …
hallmark of aging and is strongly associated with various age‐related diseases, including …
Therapeutic properties of mesenchymal stromal/stem cells: the need of cell priming for cell-free therapies in regenerative medicine
Mesenchymal stromal/stem cells (MSCs) are multipotent adult stem cells that support
homeostasis during tissue regeneration. In the last decade, cell therapies based on the use …
homeostasis during tissue regeneration. In the last decade, cell therapies based on the use …
Extensive summary of the important roles of indole propionic acid, a gut microbial metabolite in host health and disease
H Jiang, C Chen, J Gao - Nutrients, 2022 - mdpi.com
Increasing evidence suggests that metabolites produced by the gut microbiota play a crucial
role in host–microbe interactions. Dietary tryptophan ingested by the host enters the gut …
role in host–microbe interactions. Dietary tryptophan ingested by the host enters the gut …
Targeting cancer associated fibroblasts in liver fibrosis and liver cancer using nanocarriers
L Kaps, D Schuppan - Cells, 2020 - mdpi.com
Cancer associated fibroblasts (CAF) and the extracellular matrix (ECM) produced by them
have been recognized as key players in cancer biology and emerged as important targets …
have been recognized as key players in cancer biology and emerged as important targets …