NLRP3 inflammasome activation seems to be a culprit behind the chronic inflammation
characteristic of obesity and insulin resistance (IR). Nutrient excess generates danger …

Inflammasomes have recently been implicated in the pathogenesis of several chronic
inflammatory disorders, such as diabetes and obesity. The aim of this meta-analysis was to …

BACKGROUND Fasting and NAD+-boosting compounds, including NAD+ precursor
nicotinamide riboside (NR), confer antiinflammatory effects. However, the underlying …

Significance: Type 2 diabetes mellitus and hyperglycemia can lead to the development of
comorbidities such as atherosclerosis and microvascular/macrovascular complications. Both …

Caloric restriction has anti-inflammatory effects. However, the coordinated physiological
actions that lead to reduced inflammation in a state of caloric deficit (hunger) are largely …

Inflammasomes are multiprotein intracellular complexes composed of innate immune
system receptors and sensors; they activate the inflammatory cascade in response to …

Vitamin B6 serves as a coenzyme catalyzing more than 150 enzymes regulating metabolism
and synthesis of proteins, carbohydrates, lipids, heme, and important bioactive metabolites …

Background Adiponectin is an adipocytokine that plays a key regulatory role in glucose and
lipid metabolism in obesity. The prevalence of obesity has led to an increase in the …

SIRT3, the primary mitochondrial deacetylase, regulates the functions of mitochondrial
proteins including metabolic enzymes and respiratory chain components. Although SIRT3's …

Scope Cell culture studies indicate that the ketone β‐hydroxybutyrate (β‐OHB) directly
inhibits the NLRP3 inflammasome, a key regulator of inflammation. However, direct …