[HTML][HTML] Pustular psoriasis: from pathophysiology to treatment

G Genovese, C Moltrasio, N Cassano, CA Maronese… - Biomedicines, 2021 - mdpi.com
Pustular psoriasis (PP) is a clinicopathological entity encompassing different variants, ie,
acute generalized PP (GPP), PP of pregnancy (impetigo herpetiformis), annular (and …

Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis

Y Zhu, Z Wu, W Yan, F Shao, B Ke, X Jiang… - EMBO Molecular …, 2022 - embopress.org
Psoriasis is a complex chronic inflammatory skin disease with unclear molecular
mechanisms. We found that the Src homology‐2 domain‐containing protein tyrosine …

Tyrosine phosphatase SHP2 exacerbates psoriasis‐like skin inflammation in mice via ERK5‐dependent NETosis

Y Ding, Z Ouyang, C Zhang, Y Zhu, Q Xu, H Sun… - MedComm, 2022 - Wiley Online Library
Psoriasis is a chronic inflammatory skin disease, often accompanied by increased infiltration
of immune cells, especially neutrophils. However, the detailed mechanism of the neutrophil …

[HTML][HTML] SHP2 allosteric inhibitor TK-453 alleviates psoriasis-like skin inflammation in mice via inhibition of IL-23/Th17 axis

M Wang, T Li, Z Ouyang, K Tang, Y Zhu, C Song, H Sun… - Iscience, 2022 - cell.com
SHP2 is the first oncogenic tyrosine phosphatase encoded by PTPN11, which plays a
significant regulatory role in cancer and inflammation-related diseases. Although SHP2 …

SHP2‐Triggered Endothelial Cell Activation Fuels Estradiol‐Independent Endometrial Sterile Inflammation

J Pan, J Qu, W Fang, L Zhao, W Zheng… - Advanced …, 2024 - Wiley Online Library
Sterile inflammation occurs in various chronic diseases due to many nonmicrobe factors.
Examples include endometrial hyperplasia (EH), endometriosis, endometrial cancer, and …

Clinicopathologic retrospective analysis of annular pustular psoriasis

A Owczarczyk-Saczonek… - … Alpina, Pannonica et …, 2018 - go.gale.com
Annular pustular psoriasis (APP) is a rare form of pustular psoriasis with a chronic relapsing
course and a good prognosis. The clinical picture is characterized by erythematous lesions …

Inhibition of SHP2 ameliorates psoriasis by decreasing TLR7 endosome localization

Y Zhu, F Shao, W Yan, ZB Chen, B Ke, X Jiang… - medRxiv, 2020 - medrxiv.org
Psoriasis is a complex chronic inflammatory skin disease with unclear molecular
mechanisms. Here, we identify Src homology-2 domain containing protein tyrosine …

Analysis of communal Pathogenesis and Immune Infiltration Characteristics Between Psoriasis and Pulmonary Arterial Hypertension

W Su, D Luo - 2022 - researchsquare.com
Background Increasingly evidence has shown pulmonary arterial hypertension (PAH) was
predisposed to occur in psoriasis, however, the common mechanism of this phenomenon is …