Contingent upon concentration, reactive oxygen species (ROS) influence cancer evolution
in apparently contradictory ways, either initiating/stimulating tumorigenesis and supporting …

Oncogene‐induced hyper‐proliferation in cancer cells is accompanied by the onset of
different stresses, including DNA‐replication stress, metabolic stress and oxidative stress …

N-acetylcysteine (NAC) has been used as a direct scavenger of reactive oxygen species
(hydrogen peroxide, in particular) and an antioxidant in cancer biology and immuno …

NADPH oxidases (NOXs) are transmembrane enzymes that are devoted to the production of
reactive oxygen species (ROS). In cancers, dysregulation of NOX enzymes affects ROS …

Squamous cell carcinoma of the head and neck (SCCHN) is a devastating disease that
continues to have low cure rates despite the recent advances in therapies. Cisplatin is the …

The NF-κB family of transcription factors regulate the expression of genes encoding proteins
and microRNAs (miRNA, miR) precursors that may either positively or negatively regulate a …

Non-small cell lung cancer (NSCLC) accounts for 80–85% cases of lung cancer cases.
Diagnosis at advanced stages is common, after which therapy-refractory disease …

Simple Summary CHUK/IKKα has emerged as a novel tumor suppressor in several organs
of humans and mice. In general, activation of NF-κB promotes inflammation and …

Simple Summary This review discusses new findings for the roles of TNFR1 and TNFR2 in
the development of aggressive lung squamous cell carcinoma and lung adenocarcinoma by …

The tumor microenvironment (TME) provides potential targets for cancer therapy. However,
how signals originating in cancer cells affect tumor-directed immunity is largely unknown …