Acute respiratory distress syndrome: causes, pathophysiology, and phenotypes

LDJ Bos, LB Ware - The Lancet, 2022 - thelancet.com
Acute respiratory distress syndrome (ARDS) is a common clinical syndrome of acute
respiratory failure as a result of diffuse lung inflammation and oedema. ARDS can be …

Acute respiratory distress syndrome

MA Matthay, RL Zemans, GA Zimmerman… - Nature reviews Disease …, 2019 - nature.com
The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema …

Capillary cell-type specialization in the alveolus

A Gillich, F Zhang, CG Farmer, KJ Travaglini, SY Tan… - Nature, 2020 - nature.com
In the mammalian lung, an apparently homogenous mesh of capillary vessels surrounds
each alveolus, forming the vast respiratory surface across which oxygen transfers to the …

Update on the features and measurements of experimental acute lung injury in animals: an official American Thoracic Society workshop report

HS Kulkarni, JS Lee, JA Bastarache… - American journal of …, 2022 - atsjournals.org
Advancements in methods, technology, and our understanding of the pathobiology of lung
injury have created the need to update the definition of experimental acute lung injury (ALI) …

ROS signaling in the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)

M Kellner, S Noonepalle, Q Lu, A Srivastava… - … redox signaling in …, 2017 - Springer
The generation of reactive oxygen species (ROS) plays an important role for the
maintenance of cellular processes and functions in the body. However, the excessive …

An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals

G Matute-Bello, G Downey, BB Moore… - American journal of …, 2011 - atsjournals.org
Acute lung injury (ALI) is well defined in humans, but there is no agreement as to the main
features of acute lung injury in animal models. A Committee was organized to determine the …

The acute respiratory distress syndrome

LB Ware, MA Matthay - New England Journal of Medicine, 2000 - Mass Medical Soc
The acute respiratory distress syndrome is a common, devastating clinical syndrome of
acute lung injury that affects both medical and surgical patients. Since the last review of this …

[HTML][HTML] New insights into the mechanisms of pulmonary edema in acute lung injury

R Herrero, G Sanchez, JA Lorente - Annals of Translational …, 2018 - ncbi.nlm.nih.gov
Appearance of alveolar protein-rich edema is an early event in the development of acute
respiratory distress syndrome (ARDS). Alveolar edema in ARDS results from a significant …

Animal models of acute lung injury

G Matute-Bello, CW Frevert… - American Journal of …, 2008 - journals.physiology.org
Acute lung injury in humans is characterized histopathologically by neutrophilic alveolitis,
injury of the alveolar epithelium and endothelium, hyaline membrane formation, and …

Ventilator-induced lung injury: lessons from experimental studies

D Dreyfuss, G Saumon - American journal of respiratory and critical …, 1998 - atsjournals.org
Mechanical ventilation has been used to support acutely ill patients for several decades. But
clinicians are aware that, despite the life-saving potential of this assistance, it has several …