Modeling and experimental approaches for elucidating multi-scale uterine smooth muscle electro-and mechano-physiology: A review

AS Garrett, SA Means, MW Roesler, KJW Miller… - Frontiers in …, 2022 - frontiersin.org
The uterus provides protection and nourishment (via its blood supply) to a developing fetus,
and contracts to deliver the baby at an appropriate time, thereby having a critical contribution …

Progesterone control of myometrial contractility

O Shynlova, L Nadeem, S Lye - The Journal of Steroid Biochemistry and …, 2023 - Elsevier
During pregnancy, the primary function of the uterus is to be quiescent and not contract,
which allows the growing fetus to develop and mature. A uterine muscle layer, myometrium …

Steady-state approximations for Hodgkin-Huxley cell models: Reduction of order for uterine smooth muscle cell model

SA Means, MW Roesler, AS Garrett… - PLOS Computational …, 2023 - journals.plos.org
Multi-scale mathematical bioelectrical models of organs such as the uterus, stomach or heart
present challenges both for accuracy and computational tractability. These multi-scale …

[HTML][HTML] Phytochemical Analysis and Contractile Effects of Aqueous and Hydroethanolic Extracts of Anastatica hierochuntica L.(Brassicaceae) on the Isolated Uterus of …

BKWLM Esther, N Mathieu, OB Saïdath… - Pharmacology & …, 2023 - scirp.org
Background: Anastatica hierochuntica L.(Brassicaceae) has been claimed to treat various
conditions, including complicated childbirth. The principal objective of this research was to …

Mode Switch of Ca2 + Oscillation-Mediated Uterine Peristalsis and Associated Embryo Implantation Impairments in Mouse Adenomyosis

M Qu, P Lu, K Bellve, LM Lifshitz, R ZhuGe - Frontiers in Physiology, 2021 - frontiersin.org
Adenomyosis is a debilitating gynecological disease of the uterus with no medicinal cure.
The tissue injury and repair hypothesis for adenomyosis suggests that uterine …

The physiological basis with uterine myometrium contractions from electro-mechanical/hormonal myofibril function to the term and preterm labor

FZ Zangeneh, S Hantoushzadeh - Heliyon, 2023 - cell.com
Background Most labor-related problems can be attributed to the uterine myometrium
muscle, as this irritable tissue must suppress its irritability potential during pregnancy …

Multichannel mapping of in vivo rat uterine myometrium exhibits both high and low frequency electrical activity in non-pregnancy

AS Garrett, MW Roesler, ON Athavale, P Du… - Scientific Reports, 2024 - nature.com
The uterus exhibits intermittent electrophysiological activity in vivo. Although most active
during labor, the non-pregnant uterus can exhibit activity of comparable magnitude to the …

Vitamin C supplementation modulates crude oil contaminated water induced gravid uterine impaired contractile mechanism and foetal outcomes in Wistar rats

SA Salami, FO Oreagba, HM Salahdeen… - … of Complementary and …, 2023 - degruyter.com
Objectives Crude oil is a common environmental contaminant that impacts the reproductive
functions of women. Understanding the contractile mechanism of the gravid uterus and how …

Overview of the expression patterns and roles of Lipocalin 2 in the reproductive system

M Krizanac, PB Mass Sanchez… - Frontiers in …, 2024 - frontiersin.org
The 25 kDa-sized protein Lipocalin 2 (LCN2) was originally isolated from human neutrophil
granulocytes more than 30 years ago. LCN2 is an emerging player in innate immune …

Transcription Factor 23 is an Essential Determinant of Murine Term Parturition

FM Minisy, HH Shawki, T Fujita… - … and Cellular Biology, 2024 - Taylor & Francis
Pregnancy involving intricate tissue transformations governed by the progesterone hormone
(P4). P4 signaling via P4 receptors (PRs) is vital for endometrial receptivity, decidualization …