[HTML][HTML] Natural medicine in neuroprotection for ischemic stroke: Challenges and prospective

T Tao, M Liu, M Chen, Y Luo, C Wang, T Xu… - Pharmacology & …, 2020 - Elsevier
There is a growing interest in using natural medicines to treat stroke as the leading cause of
disability worldwide. Especially plant-derived natural medicines have multiple beneficial …

Multifunctional compounds: Smart molecules for multifactorial diseases

Y Bansal, O Silakari - European Journal of Medicinal Chemistry, 2014 - Elsevier
Multifunctional compounds (MFCs) are designed broadly as hybrid or conjugated drugs or
as chimeric drugs from two or more pharmacophores/drugs having specific pharmacological …

50/50 oil/water emulsion stabilized by pea protein isolate microgel particles/xanthan gum complexes and co-emulsifiers

S Li, B Jiao, S Faisal, Y Zhang, B Wu, W Li, A Shi… - Food …, 2023 - Elsevier
Abstract Properties of 50/50 oil/water emulsion stabilized by pea protein isolate microgel
particles (PPIMP)/xanthan gum (XG) and co-emulsifiers were evaluated. Three surfactants …

[HTML][HTML] Mitochondrial MPTP: a novel target of ethnomedicine for stroke treatment by apoptosis inhibition

Y Li, J Sun, R Wu, J Bai, Y Hou, Y Zeng… - Frontiers in …, 2020 - frontiersin.org
Mammalian mitochondrial permeability transition pore (MPTP), across the inner and outer
membranes of mitochondria, is a nonspecific channel for signal transduction or material …

Age-associated neurodegeneration and oxidative damage to lipids, proteins and DNA

Z Radak, Z Zhao, S Goto, E Koltai - Molecular aspects of medicine, 2011 - Elsevier
Lipids, proteins and DNA in the central nervous system have a high sensitivity to oxidative
stress. Reactive oxygen species (ROS)-induced damage increases with aging, especially in …

Multiomics analyses of two Leonurus species illuminate leonurine biosynthesis and its evolution

P Li, MX Yan, P Liu, DJ Yang, ZK He, Y Gao, Y Jiang… - Molecular Plant, 2024 - cell.com
The Lamiaceae family is renowned for its terpenoid-based medicinal components, but
Leonurus, which has traditional medicinal uses, stands out for its alkaloid-rich composition …

[HTML][HTML] Leonurus japonicus (Chinese motherwort), an excellent traditional medicine for obstetrical and gynecological diseases: A comprehensive overview

LL Miao, QM Zhou, C Peng, ZH Liu, L Xiong - Biomedicine & …, 2019 - Elsevier
Leonurus japonicus Houtt. is a traditional medicinal herb with significant effects; dating back
more than 1800 years, it is widely used in Asia. In traditional Chinese medicine, it is …

[HTML][HTML] Energy-stress-mediated AMPK activation promotes GPX4-dependent ferroptosis through the JAK2/STAT3/P53 axis in renal cancer

Y Li, Y Zhang, Q Qiu, L Wang, H Mao, J Hu… - … medicine and cellular …, 2022 - hindawi.com
Energy stress is an unfavorable condition that tumor cells are often exposed to. Ferroptosis
is considered an emerging target for tumor therapy. However, the role of ferroptosis in …

Sustainable production of active pharmaceutical ingredients from lignin-based benzoic acid derivatives via “demand orientation”

Y Dong, L Dong, X Gu, Y Wang, Y Liao, R Luque… - Green …, 2023 - pubs.rsc.org
Research related to lignin valorization into fine chemicals is an extremely demanding task
due to the wide distribution and low economic value of depolymerization products. Benzoic …

Success stories of natural product-based hybrid molecules for multi-factorial diseases

S Choudhary, PK Singh, H Verma, H Singh… - European journal of …, 2018 - Elsevier
Complex diseases comprises of highly complicated etiology resulting in limited applicability
of conventional targeted therapies. Consequently, conventional medicinal compounds suffer …