Physically cross-linked hydrogels are used as scaffolds in tissue engineering applications
because they are easily produced and avoid the potential toxicity produced by chemical …

Cartilage tissue is under extensive investigation in tissue engineering and regenerative
medicine studies because of its limited regenerative potential. Currently, many scaffolds are …

Articular cartilage defects are prevalent and are potentially involved in the initiation of
osteoarthritis, yet the lack of efficient therapeutic options to treat cartilage defects represents …

Natural polymeric scaffolds can be used for tissue engineering applications such as cell
delivery and cell-free supporting of native tissues. This is because of their desirable …

Immunoengineering continues to revolutionize healthcare, generating new approaches for
treating previously intractable diseases, particularly in regard to cancer immunotherapy. In …

Background: Matrix-induced chondrogenesis (MIC) is a promising treatment option for
critical-size cartilage lesions of the knee; however, there exists substantial heterogeneity in …

Background Osteochondral lesions of the talus (OLT) are common after ankle trauma.
Studies have shown that bioactive substances, such as hyaluronic acid (HA), alone, or in …

Purpose Osteochondral implants are currently adopted for the treatment of symptomatic full-
thickness chondral and osteochondral defects. Agili-C™ is a cell-free aragonite-based …

Objective To evaluate current evidence and results of cell-free scaffold techniques for knee
chondral lesions. Design A systematic review was conducted on 3 medical electronic …

Despite critical advances in regenerative medicine, the generation of definitive, reliable
treatments for musculoskeletal diseases remains challenging. Gene therapy based on the …