Gastric cancer constitutes one of the most prevalent malignancies in both sexes; it is
currently the fourth major cause of cancer-related deaths worldwide. The pathogenesis of …

Chronic infection with Helicobacter pylori cagA-positive strains is the strongest risk factor for
gastric cancer. The cagA gene product, CagA, is delivered into gastric epithelial cells via the …

Helicobacter pylori colonizes the gastric epithelial cells of at least half of the world's
population, and it is the strongest risk factor for developing gastric complications like chronic …

Worldwide, gastric cancer (GC) represents the fifth cancer for incidence, and the third as
cause of death in developed countries. Indeed, it resulted in more than 780,000 deaths in …

Helicobacter pylori (H. pylori) is transmitted primarily through the oral–oral route and fecal–
oral route. The oral cavity had therefore been hypothesized as an extragastric reservoir of H …

Life-threatening bacterial infections in women after childbirth, known as puerperal sepsis,
resulted in classical epidemics and remain a global health problem. While outbreaks of …

The type I membrane protein receptor carcinoembryonic antigen-related cell adhesion
molecule 1 (CEACAM1) distinctively exhibits significant alternative splicing that allows for …

NF-κB signaling pathways, induced by a variety of triggers, play a key role in regulating the
expression of genes involved in the immune response and cellular responses to stress. The …

Helicobacter pylori has developed several strategies using its diverse virulence factors to
trigger and, at the same time, limit the host's inflammatory responses in order to establish a …

The cag type IV secretion system (cag-T4SS) of Helicobacter pylori exploits specific cellular
carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), such as CEACAM1 …