[HTML][HTML] Interleukin-18 and high-mobility-group-protein B1 are early and sensitive indicators for cell damage during normothermic machine perfusion after prolonged …

O Beetz, S Cammann, CA Weigle… - Transplant …, 2022 - frontierspartnerships.org
In the era of organ machine perfusion, experimental models to optimize reconditioning of
(marginal) liver grafts are needed. Although the relevance of cytokine signatures in liver …

[HTML][HTML] A surgical method for continuous intraportal infusion of gut microbial metabolites in mice

D Orabi, LJ Osborn, K Fung, W Massey, AJ Horak III… - JCI insight, 2021 - ncbi.nlm.nih.gov
Gut microbe–derived metabolites influence human physiology and disease. However,
establishing mechanistic links between gut microbial metabolites and disease pathogenesis …

[HTML][HTML] Supportive hepatocyte transplantation after partial hepatectomy enhances liver regeneration in a preclinical pig model

F Oldhafer, EM Wittauer, O Beetz, CA Weigle… - European Surgical …, 2021 - karger.com
Background: Hepatocyte transplantation (HTx) is regarded as a potential treatment modality
for various liver diseases including acute liver failure. We developed a preclinical pig model …

A novel surgical method for continuous intra-portal infusion of gut microbial metabolites in mice

D Orabi, LJ Osborn, K Fung, F Aucejo, I Choucair… - bioRxiv, 2020 - biorxiv.org
Gut microbial-derived metabolites have been shown to play key roles in human physiology
and disease. However, establishing mechanistic links between gut microbial metabolites …

[图书][B] Microbial Metabolism of Dietary Input in Cardiometabolic disease Pathogenesis

LJ Osborn - 2021 - search.proquest.com
Objective–The dietary contribution to human health and disease has been long appreciated.
However, the metabolism of dietary substrates by commensal gut microbiota and ultimately …

[PDF][PDF] POSSIBILITIES OF ENDOPORTAL INFUSION THERAPY FOR INTRA-ABDOMINAL SURGICAL INFECTIONS COMPLICATED BY ACUTE INTESTINAL …

D Parshin, V Mykhaylichenko, A Butyrskii, I Mukaramov… - researchgate.net
The purpose of this study was to evaluate the effectiveness of EIT for intra-abdominal
infections complicated by acute intestinal failure. Materials and Methods: The authors …