The first scientific attempts to control an infectious disease can be attributed to Edward
Jenner, who, in 1796 inoculated an 8-year-old boy with cowpox (vaccinia), giving the boy …

Vaccines are the most effective and inexpensive prophylactic tool in veterinary medicine.
Ideally, vaccines should induce a lifelong protective immunity against the target pathogen …

A recombinant replication-defective human adenovirus serotype 5 vector containing FMDV
capsid, P1-2A, and viral 3C protease coding regions was constructed. Two viral clones were …

Although recombinant human adenovirus (HAV)-based vectors offer several advantages for
somatic gene therapy and vaccination over other viral vectors, it would be desirable to …

The majority of pathogens enter the body through mucosal surfaces and it is now evident
that mucosal immunity can provide effective disease protection. However, the induction of …

Vaccination continues to be the main approach to protecting animals from infectious
diseases. Until recently, all licensed vaccines were developed using conventional …

None of the currently available distemper vaccines provides a satisfactory solution for the
immunization of very young carnivores in the face of maternal-derived immunity. Since …

To determine the potential of replication-competent (E3-deleted) bovine adenovirus-3 (BAV-
3) as a delivery system for vaccine antigens in calves, we evaluated the ability of …

Immunization of mucosal surfaces has become an attractive route of vaccine delivery
because of its ability to induce mucosal immunity. Although various methods of inducing …

Replication-defective human adenoviruses type 5 (HAd5) expressing the bovine
herpesvirus type 1 (BHV-1) glycoprotein gC or gD under the control of the human …