RNA methylation influences TDP43 binding and disease pathogenesis in models of amyotrophic lateral sclerosis and frontotemporal dementia
RNA methylation at adenosine N6 (m6A) is one of the most common RNA modifications,
impacting RNA stability, transport, and translation. Previous studies uncovered RNA …
impacting RNA stability, transport, and translation. Previous studies uncovered RNA …
Cryptic exon detection and transcriptomic changes revealed in single-nuclei RNA sequencing of C9ORF72 patients spanning the ALS-FTD spectrum
LM Gittings, EB Alsop, J Antone, M Singer… - Acta …, 2023 - Springer
The C9ORF72-linked diseases amyotrophic lateral sclerosis (ALS) and frontotemporal
dementia (FTD) are characterized by the nuclear depletion and cytoplasmic accumulation of …
dementia (FTD) are characterized by the nuclear depletion and cytoplasmic accumulation of …
[HTML][HTML] FDA-approved disulfiram inhibits the NLRP3 inflammasome by regulating NLRP3 palmitoylation
The NLRP3 inflammasome is dysregulated in autoinflammatory disorders caused by
inherited mutations and contributes to the pathogenesis of several chronic inflammatory …
inherited mutations and contributes to the pathogenesis of several chronic inflammatory …
Upregulation of β-catenin due to loss of miR-139 contributes to motor neuron death in amyotrophic lateral sclerosis
S Hawkins, SC Namboori, A Tariq, C Blaker… - Stem Cell Reports, 2022 - cell.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
the loss of motor neurons (MNs). There are no effective treatments and patients usually die …
the loss of motor neurons (MNs). There are no effective treatments and patients usually die …
Loss of Tdp-43 disrupts the axonal transcriptome of motoneurons accompanied by impaired axonal translation and mitochondria function
M Briese, L Saal-Bauernschubert… - Acta neuropathologica …, 2020 - Springer
Protein inclusions containing the RNA-binding protein TDP-43 are a pathological hallmark
of amyotrophic lateral sclerosis and other neurodegenerative disorders. The loss of TDP-43 …
of amyotrophic lateral sclerosis and other neurodegenerative disorders. The loss of TDP-43 …
Multiple TonB homologs are important for carbohydrate utilization by Bacteroides thetaiotaomicron
The human gut microbiota is able to degrade otherwise undigestible polysaccharides,
largely through the activity of Bacteroides. Uptake of polysaccharides into Bacteroides is …
largely through the activity of Bacteroides. Uptake of polysaccharides into Bacteroides is …
Inhibition of nonsense-mediated decay induces nociceptive sensitization through activation of the integrated stress response
RNA stability is meticulously controlled. Here, we sought to determine whether an essential
post-transcriptional regulatory mechanism plays a role in pain. Nonsense-mediated decay …
post-transcriptional regulatory mechanism plays a role in pain. Nonsense-mediated decay …
Abundant transcriptomic alterations in the human cerebellum of patients with a C9orf72 repeat expansion
The most prominent genetic cause of both amyotrophic lateral sclerosis (ALS) and
frontotemporal lobar degeneration (FTLD) is a repeat expansion in the gene C9orf72 …
frontotemporal lobar degeneration (FTLD) is a repeat expansion in the gene C9orf72 …
[PDF][PDF] Nidhi S. Dey, 4 Peter Henley, Andrew Randall, Alessandro Rosa, 5, 6 Lawrence W. Stanton, 7 and Akshay Bhinge
S Hawkins, SC Namboori, A Tariq, C Blaker… - iris.uniroma1.it
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
the loss of motor neurons (MNs). There are no effective treatments and patients usually die …
the loss of motor neurons (MNs). There are no effective treatments and patients usually die …