Adipocyte and lipid metabolism in cancer drug resistance

Y Cao - The Journal of clinical investigation, 2019 - Am Soc Clin Investig
Development of novel and effective therapeutics for treating various cancers is probably the
most congested and challenging enterprise of pharmaceutical companies. Diverse drugs …

Mesenchymal stromal cells as critical contributors to tissue regeneration

GD Sagaradze, NA Basalova, AY Efimenko… - Frontiers in cell and …, 2020 - frontiersin.org
Adult stem cells that are tightly regulated by the specific microenvironment, or the stem cell
niche, function to maintain tissue homeostasis and regeneration after damage. This …

The role of mesenchymal stem cells in radiation-induced lung fibrosis

M Zanoni, M Cortesi, A Zamagni, A Tesei - International journal of …, 2019 - mdpi.com
Radiation therapy is one of the most important treatment modalities for thoracic tumors.
Despite significant advances in radiation techniques, radiation-induced lung injury (RILI) still …

Consequences of irradiation on bone and marrow phenotypes, and its relation to disruption of hematopoietic precursors

DE Green, CT Rubin - Bone, 2014 - Elsevier
The rising levels of radiation exposure, specifically for medical treatments and accidental
exposures, have added great concern for the long term risks of bone fractures. Both the …

Low dose radiation induced senescence of human mesenchymal stromal cells and impaired the autophagy process

N Alessio, S Del Gaudio, S Capasso… - …, 2014 - pmc.ncbi.nlm.nih.gov
Low doses of radiation may have profound effects on cellular function. Individuals may be
exposed to low doses of radiation either intentionally for medical purposes or accidentally …

Ginger Oleoresin Alleviated γ‐Ray Irradiation‐Induced Reactive Oxygen Species via the Nrf2 Protective Response in Human Mesenchymal Stem Cells

K Ji, L Fang, H Zhao, Q Li, Y Shi, C Xu… - Oxidative Medicine …, 2017 - Wiley Online Library
Unplanned exposure to radiation can cause side effects on high‐risk individuals;
meanwhile, radiotherapies can also cause injury on normal cells and tissues surrounding …

Suppression of sclerostin alleviates radiation‐induced bone loss by protecting bone‐forming cells and their progenitors through distinct mechanisms

A Chandra, T Lin, T Young, W Tong… - Journal of Bone and …, 2017 - academic.oup.com
Focal radiotherapy is frequently associated with skeletal damage within the radiation field.
Our previous in vitro study showed that activation of Wnt/β‐catenin pathway can overcome …

[HTML][HTML] Radio-resistant mesenchymal stem cells: mechanisms of resistance and potential implications for the clinic

NH Nicolay, RL Perez, R Saffrich, PE Huber - Oncotarget, 2015 - ncbi.nlm.nih.gov
Mesenchymal stem cells (MSCs) comprise a heterogeneous population of multipotent
stromal cells and can be isolated from various tissues and organs. Due to their regenerative …

Mesenchymal stem cells–A new hope for radiotherapy-induced tissue damage?

NH Nicolay, RL Perez, J Debus, PE Huber - Cancer letters, 2015 - Elsevier
Mesenchymal stem cells (MSCs) have been isolated from various organ sites including
bone marrow, skin, vascular and adipose tissues and form a heterogeneous population of …

Mesenchymal stem cells retain their defining stem cell characteristics after exposure to ionizing radiation

NH Nicolay, E Sommer, R Lopez, U Wirkner… - International Journal of …, 2013 - Elsevier
Purpose Mesenchymal stem cells (MSCs) have the ability to migrate to lesion sites and
undergo differentiation into functional tissues. Although this function may be important for …