Diabetes mellitus, which affects more than 463 million people globally, is caused by the
autoimmune ablation or functional loss of insulin-producing β-cells, and prevalence is …

Transplantation of live cells as therapeutic agents is poised to offer new treatment options for
a wide range of acute and chronic diseases. However, the biological complexity of cells has …

Organoid models of early tissue development have been produced for the intestine, brain,
kidney and other organs, but similar approaches for the heart have been lacking. Here we …

Despite proven efficacy of pharmacotherapies targeting primarily global neurohormonal
dysregulation, heart failure (HF) is a growing pandemic with increasing burden. Treatments …

Since the advent of the generation of human induced pluripotent stem cells (hiPSCs),
numerous protocols have been developed to differentiate hiPSCs into cardiomyocytes and …

Cardiomyocytes from human pluripotent stem cells (hPSCs-CMs) could revolutionise
biomedicine. Global burden of heart failure will soon reach USD $90 bn, while unexpected …

Differentiated cells can be reprogrammed to an embryonic-like state by transfer of nuclear
contents into oocytes or by fusion with embryonic stem (ES) cells. Little is known about …

Recent studies highlighted long noncoding RNAs (lncRNAs) to play an important role in
cardiac development. However, understanding of lncRNAs in cardiac diseases is still …

The constant supply of high cell numbers generated by defined, robust, and economically
viable culture processes is indispensable for the envisioned application of human …

Stem cell-derived sheet engineering has been developed as the next-generation treatment
for myocardial infarction (MI) and offers attractive advantages in comparison with direct stem …