Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis
Natural killer cells can discriminate between normal cells and cells that do not express
adequate amounts of major histocompatibility complex (MHC) class I molecules. The …
adequate amounts of major histocompatibility complex (MHC) class I molecules. The …
The role of the cytoskeleton in regulating the natural killer cell immune response in health and disease: from signaling dynamics to function
A Ben-Shmuel, B Sabag, G Biber… - Frontiers in cell and …, 2021 - frontiersin.org
Natural killer (NK) cells are innate lymphoid cells, which play key roles in elimination of
virally infected and malignant cells. The balance between activating and inhibitory signals …
virally infected and malignant cells. The balance between activating and inhibitory signals …
Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia
A Crinier, PY Dumas, B Escalière… - Cellular & molecular …, 2021 - nature.com
Natural killer (NK) cells are innate cytotoxic lymphoid cells (ILCs) involved in the killing of
infected and tumor cells. Among human and mouse NK cells from the spleen and blood, we …
infected and tumor cells. Among human and mouse NK cells from the spleen and blood, we …
Natural killer cell signaling pathways
E Vivier, JA Nunès, F Vély - Science, 2004 - science.org
Natural killer (NK) cells are lymphocytes of the innate immune system that are involved in
the early defenses against foreign cells, as well as autologous cells undergoing various …
the early defenses against foreign cells, as well as autologous cells undergoing various …
Essential role of LAT in T cell development
W Zhang, CL Sommers, DN Burshtyn, CC Stebbins… - Immunity, 1999 - cell.com
The linker molecule LAT is a substrate of the tyrosine kinases activated following TCR
engagement. Phosphorylated LAT binds many critical signaling molecules. The central role …
engagement. Phosphorylated LAT binds many critical signaling molecules. The central role …
NKG2D-DAP10 triggers human NK cell–mediated killing via a Syk-independent regulatory pathway
DD Billadeau, JL Upshaw, RA Schoon, CJ Dick… - Nature …, 2003 - nature.com
The immune recognition receptor complex NKG2D-DAP10 on natural killer cells is
stimulated by specific ligands carried on virus-infected and malignant cells. Because DAP10 …
stimulated by specific ligands carried on virus-infected and malignant cells. Because DAP10 …
LAT is essential for FcεRI-mediated mast cell activation
S Saitoh, R Arudchandran, TS Manetz, W Zhang… - Immunity, 2000 - cell.com
The linker molecule LAT is a substrate of the tyrosine kinases activated following TCR
engagement of T cells. LAT is also expressed in platelets, NK, and mast cells. Although LAT …
engagement of T cells. LAT is also expressed in platelets, NK, and mast cells. Although LAT …
Transmembrane adaptor proteins: organizers of immunoreceptor signalling
V Hořejší, W Zhang, B Schraven - Nature Reviews Immunology, 2004 - nature.com
Signalling through multichain immunoreceptors is required for the development, activation
and differentiation of haematopoietic cells. One of the most challenging questions with …
and differentiation of haematopoietic cells. One of the most challenging questions with …
Spatial organization of signal transduction molecules in the NK cell immune synapses during MHC class I-regulated noncytolytic and cytolytic interactions
YM Vyas, KM Mehta, M Morgan, H Maniar… - The Journal of …, 2001 - journals.aai.org
The cytolytic activity of NK cells is tightly regulated by inhibitory receptors specific for MHC
class I Ags. We have investigated the composition of signal transduction molecules in the …
class I Ags. We have investigated the composition of signal transduction molecules in the …
Natural killer cell activation in mice and men: different triggers for similar weapons?
F Colucci, JP Di Santo, PJ Leibson - Nature immunology, 2002 - nature.com
The signaling pathways that regulate B and T lymphocytes are remarkably conserved
between humans and mice. However, recent evidence suggests that the pathways …
between humans and mice. However, recent evidence suggests that the pathways …