Hormonal regulation of spermatogenesis and spermiogenesis

N Sofikitis, N Giotitsas, P Tsounapi… - The Journal of steroid …, 2008 - Elsevier
Normal testicular function is dependent upon hormones acting through endocrine and
paracrine pathways both in vivo and in vitro. Sertoli cells provide factors necessary for the …

Peritoneal environment, cytokines and angiogenesis in the pathophysiology of endometriosis

R Gazvani, A Templeton - Reproduction, 2002 - rep.bioscientifica.com
Granulosa cells play an essential role in follicular development and formation of corpora
lutea. Many functions of granulosa-lutein cells are controlled by activation of G protein …

Phase II study of imatinib in advanced chordoma

S Stacchiotti, A Longhi, V Ferraresi… - Journal of Clinical …, 2012 - ascopubs.org
Purpose To explore the antitumor activity of imatinib in patients with advanced platelet-
derived growth factor β (PDGFB)/PDGF receptor β (PDGFRB)–positive chordomas. Patients …

Contribution of Leydig and Sertoli cells to testosterone production in mouse fetal testes

Y Shima, K Miyabayashi, S Haraguchi… - Molecular …, 2013 - academic.oup.com
Testosterone is a final product of androgenic hormone biosynthesis, and Leydig cells are
known to be the primary source of androgens. In the mammalian testis, two distinct …

In search of rat stem Leydig cells: identification, isolation, and lineage-specific development

RS Ge, Q Dong, CM Sottas… - Proceedings of the …, 2006 - National Acad Sciences
Leydig cells (LCs) are thought to differentiate from spindle-shaped precursor cells that
exhibit some aspects of differentiated function, including 3β-hydroxysteroid dehydrogenase …

Morphological and functional maturation of Leydig cells: from rodent models to primates

KJ Teerds, IT Huhtaniemi - Human reproduction update, 2015 - academic.oup.com
BACKGROUND Leydig cells (LC) are the sites of testicular androgen production.
Development of LC occurs in the testes of most mammalian species as two distinct growth …

Progenitor cells of the testosterone-producing Leydig cells revealed

MS Davidoff, R Middendorff, G Enikolopov… - The Journal of cell …, 2004 - rupress.org
The cells responsible for production of the male sex hormone testosterone, the Leydig cells
of the testis, are post-mitotic cells with neuroendocrine characteristics. Their origin during …

Proteomic analysis of seminal plasma from normal volunteers and post-vasectomy patients identifies over 2000 proteins and candidate biomarkers of the urogenital …

I Batruch, I Lecker, D Kagedan, CR Smith… - Journal of proteome …, 2011 - ACS Publications
Seminal plasma is a fluid that originates from the testis, epididymis, prostate, and seminal
vesicles, and hence, proteomic studies may identify potential markers of infertility and other …

Origin, development and regulation of human Leydig cells

K Svechnikov, L Landreh, J Weisser, G Izzo… - Hormone research in …, 2010 - karger.com
Sex steroids are crucial regulators of sexual differentiation and the proper development of
secondary sex characteristics and patterns of sexual behavior. Since Leydig cells are the …

Leydig cell stem cells: Identification, proliferation and differentiation

H Chen, Y Wang, R Ge, BR Zirkin - Molecular and cellular endocrinology, 2017 - Elsevier
Adult Leydig cells develop from undifferentiated mesenchymal-like stem cells (stem Leydig
cells, SLCs) present in the interstitial compartment of the early postnatal testis. Putative …