[PDF][PDF] IL-21 lowers the B cell receptor affinity threshold for participation in a T cell dependent immune response
The cytokine IL-21 is a regulator of B cell responses, increasing antibody quantity and
quality. Here, we report IL-21's role during germinal center initiation, where it increases the …
quality. Here, we report IL-21's role during germinal center initiation, where it increases the …
IL-21 lowers the B cell receptor affinity threshold for participation in a T cell dependent immune response
AR Dvorscek, CI McKenzie, MJ Robinson, Z Ding… - bioRxiv, 2022 - biorxiv.org
The expansion of antigen-specific T and B cells and generation of germinal centers (GC) are
prerequisites for long-lasting, high-affinity antibody-mediated immune protection. Affinity for …
prerequisites for long-lasting, high-affinity antibody-mediated immune protection. Affinity for …