… cytokines in the regulation of the immune response in sepsis. The actions of individual pro-
and anti-inflammatory cytokines … and are directly associated with sepsis pathophysiology (see …

… response required for the clearance of bacterial infection [44]. Although a large portion of
sepsis patients might die during the initial cytokine storm, patients who survive this stage could …

… Pro-inflammatory cytokines implicated in sepsis pathogenesis include tumour necrosis …
eliminating these cytokines confers protection in acute animal models of fulminant infection 10 . …

… In summary, while the innate immune system is rich in potential therapeutic targets and
remains a promising area of research, as has been demonstrated by the study of cytokines in this …

… , animal studies clearly indicate that females are better positioned to tolerate trauma and
sepsis. Estrogens have been shown to normalize cytokine release, Th1-to-Th2 balance, …

… produce a variety of cytokines known to play important roles in inflammatory processes. In
this review, I will focus on the biology of PMN-derived cytokines and discuss their regulation …

… overview of the mechanisms and potential therapeutic targets underlying pyroptosis in sepsis
identified in recent decades, looking forward to the future direction of treatment for sepsis. …

… , which is seen as the primary driver of sepsis pathogenesis. Throughout the onset and
progression of sepsis, the generation of cytokines not only facilitates the activation of coagulation …

… to mitigate the devastating effects of sepsis and multiple organ failure in the critically ill
patient indicates that more knowledge of the pathophysiology of sepsis is needed if we are to …

… cytokine profile that is rarely attained in clinical sepsis [5, 6]. … point in the chronology of the
sepsis syndrome will be critical to … Therefore, all of the potential therapeutic targets described …