Therapeutic strategies for Parkinson disease: beyond dopaminergic drugs

D Charvin, R Medori, RA Hauser… - Nature Reviews Drug …, 2018 - nature.com
… In addition to dopaminergic neuropathology, there is … with dopamine system dysfunction
and/or dopaminergic neuronal … process affecting dopaminergic and non-dopaminergic systems (…

Factors associated with dopaminergic drug–related pathological gambling in Parkinson disease

V Voon, T Thomsen, JM Miyasaki… - Archives of …, 2007 - jamanetwork.com
… to adjuvant dopamine agonist therapy in Parkinson's disease and multiple system atrophy. …
AJ Hedonistic homeostatic dysregulation in patients with Parkinson's disease on dopamine

Contributions of dopaminergic drugs and disease severity to daytime sleepiness in Parkinson disease

PE O'Suilleabhain, RB Dewey Jr - Archives of neurology, 2002 - jamanetwork.com
… dosing and sedation, we reduce or change the offending drug. We compromise motor control
by reducing dopaminergic drugs only among the subset of patients with intolerance to all …

Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment

KR Chaudhuri, AHV Schapira - The Lancet Neurology, 2009 - thelancet.com
… The role of dopaminergic drugs in treating the various non-… In this Review, we investigate
the dopaminergic basis of the … in part, with various dopaminergic strategies and, where relevant…

Association between the dose of dopaminergic medication and the behavioral disturbances in Parkinson disease

JY Lee, JM Kim, JW Kim, J Cho, WY Lee, HJ Kim… - Parkinsonism & related …, 2010 - Elsevier
… In order to evaluate the relationship between the dose of dopaminergic drugs and the
development of an ICRB, we conducted three separate multivariate logistic regression analyses. …

Therapies for dopaminergic‐induced dyskinesias in parkinson disease

MD Gottwald, MJ Aminoff - Annals of neurology, 2011 - Wiley Online Library
… ) in patients with Parkinson disease have … dopaminergic stimulation, or using novel agents
that target receptors implicated in the mechanisms underlying LIDs. Treatment with dopamine

Pharmacological treatment of Parkinson disease: a review

BS Connolly, AE Lang - Jama, 2014 - jamanetwork.com
… centrally to dopamine, replacing the neurotransmitter deficient in Parkinson disease. Outside
the blood-brain barrier, in the peripheral circulation, dopamine decarboxylase inhibitors (…

Factors influencing susceptibility to compulsive dopaminergic drug use in Parkinson disease

AH Evans, AD Lawrence, J Potts, S Appel, AJ Lees - Neurology, 2005 - AAN Enterprises
… to take dopaminergic drugs becomes pathologically … leads to compulsive dopaminergic drug
use 1,2 —the dopamine … brain dopamine systems mediating reward by dopaminergic drugs

Mechanism of action of dopaminergic agents in Parkinson's disease

WC Koller, MG Rueda - Neurology, 1998 - AAN Enterprises
… How the actions of dopaminergic drugs produce side effects and how … Dopaminergic drugs,
levodopa and dopamine agonists, are highly effective in the treatment of Parkinson's disease

Drug insight: continuous dopaminergic stimulation in the treatment of Parkinson's disease

CW Olanow, JA Obeso, F Stocchi - Nature clinical practice Neurology, 2006 - nature.com
… Continuous dopaminergic stimulation is a therapeutic strategy … of Parkinson's disease, which
proposes that dopaminergic agents that provide continuous stimulation of striatal dopamine