… utility and safety of human challenge studies in the evaluation of DENV vaccine candidates.
There has been much debate regarding the use of human challenge studies in this context …

… has been an ambitious task due to the presence of four different dengue serotypes … the
ongoing challenges in the construction of a dengue vaccine and the current status of the vaccine …

… of dengue vaccination, and discusses the challenges that … Finally, an ongoing clinical trial
led by WRAIR is addressing … two dengue vaccine candidates, namely the inactivated vaccine …

… WHO does not recommend vaccination during an ongoing outbreak as a control measure.
A decline in hospitalization rate by 10–30% over a period of 30 years is estimated through the …

… severe dengue in young, vaccinated recipients. … a dengue vaccine. In this review we have
conducted a detailed overview of the DENV vaccine landscape, focusing on nine vaccines in …

… TV003/TV005 (NCT01506570) and TDV/DENVax/TAK003 (NCT02302066) are two promising
live-attenuated vaccine candidates currently ongoing in phase 3 clinical trials (39, 40). …

… value of a protective vaccine is clear. This review considers some of … challenges to dengue
vaccine development, and in particular the challenges of demonstrating dengue vaccine …

… dengue vaccine and no prophylactic or therapeutic dengue … dengue vaccine is the best
strategy for reducing the global … remote from vaccination (ie, >6 months) are ongoing.108 All …

… to making the task of developing a dengue vaccine a formidable one. Global awareness
of dengue in recent years has kindled renewed interest in developing dengue vaccines. …

… Long-term safety assessment capturing hospitalized cases of dengue through passive
surveillance is ongoing in phase IIb and III efficacy trials (see below; 86–88). Figure 3 presents a …