… whether drug-specific TCR clonotypes mediate the hypersensitivity reactions. In this study, …
Here, we report the discovery of preferential TCR clonotypes from the blister cells of the skin …

… Allopurinol, a first-line drug for treating gout and hyperuricemia, is one of the leading causes
of severe cutaneous adverse reactions (SCARs). To investigate the molecular mechanism …

… lesions/blisters of SCAR patients, and there were very limited TCR clonotypes been …
HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by …

… overlap of TCR clonotypes between tumor and irAE tissues8–10 and that expansion of
peripheral blood T-cell clones prior to irAE onset positively correlates with irAE severity during …

… (SCARs) are a group of adverse reactions resulting from drug-induced T cell-mediated
hypersensitivity characterized by severe skin eruptions and varying degrees of systemic …

… a life-threatening cutaneous adverse drug reaction. To better understand why skin symptoms
are so severe, we conducted a prospective immunophenotyping study on skin and blood. …

… Further studies correlating clinical response with TCR clonotypes and usages by malignant
T-… We also plan to apply DTEA to skin samples of MF/SS patients and assess its value in the …

… severe cutaneous adverse drug reactions characterized by widespread epidermal necrosis.
Recent studies have indicated that SJS/TEN is a specific immune reaction … TCR clonotypes …

… All TCR clonotypes detected were considered in the analysis, irrespective of their functionality
(productive or unproductive). All samples were sequenced in duplicates yielding similar …

… By comparing TCR clonotypes in the skin and blood in patients with MF, we reveal a
complex pattern of recirculation of tumor subclones. We propose that the substantial clonotypic …