Associations between HLA class I and cytochrome P450 2C9 genetic polymorphisms and phenytoin-related severe cutaneous adverse reactions in a Thai population

W Tassaneeyakul, N Prabmeechai… - Pharmacogenetics …, 2016 - journals.lww.com
… of several types of severe cutaneous adverse reactions (SCAR) such as Stevens–Johnson
syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reactions with eosinophilia and …

Genetic Determinants in HLA and Cytochrome P450 Genes in the Risk of Aromatic Antiepileptic-Induced Severe Cutaneous Adverse Reactions

AF Ahmed, C Sukasem, MA Sabbah, NF Musa… - Journal of Personalized …, 2021 - mdpi.com
… This has become apparent in the event of severe cutaneous adverse reactions (SCARs),
which can be life-threatening. In this review, four hypotheses were identified to describe how …

Genetic polymorphism of cytochrome P 450 2C9 in diphenylhydantoin-induced cutaneous adverse drug reactions

AY Lee, MJ Kim, WY Chey, J Choi, BG Kim - European journal of clinical …, 2004 - Springer
… for DPH-induced skin reactions. Therefore, … adverse reactions. However, the small sample
size in this study indicates that further studies on patients with DPH-induced skin reactions are …

Association analysis of CYP2C9* 3 and phenytoin-induced severe cutaneous adverse reactions (SCARs) in Thai epilepsy children

S Suvichapanich, J Jittikoon, N Wichukchinda… - Journal of human …, 2015 - nature.com
… symptoms (DRESS) are considered Severe Cutaneous Adverse Reactions (SCARs). SJS …
:02, which has been strongly associated with serious skin reactions, in ancestry across broad …

Association of CYP 2C9* 3 with phenytoin‐induced Stevens‐Johnson syndrome and toxic epidermal necrolysis: A systematic review and meta‐analysis

X Wu, W Liu, W Zhou - Journal of Clinical Pharmacy and …, 2018 - Wiley Online Library
… included “cytochrome P450 2C9” OR “CYP2C9” AND “phenytoin” AND “Stevens-Johnson
syndrome” OR “toxic epidermal necrolysis” OR “severe cutaneous adverse reactions.” There …

Clinical consequences of cytochrome P450 2C9 polymorphisms

J Kirchheiner, J Brockmöller - Clinical Pharmacology & …, 2005 - Wiley Online Library
… with severe adverse events or greatly enhanced effects and … most severe cases of adverse
events or exaggerated effectsadverse effects will not be cost-effective unless the toxicity is …

HLA-B*13 :01 Is a Predictive Marker of Dapsone-Induced Severe Cutaneous Adverse Reactions in Thai Patients

P Satapornpong, J Pratoomwun, P Rerknimitr… - Frontiers in …, 2021 - frontiersin.org
… However, studies have not highlighted the importance of other genetic polymorphisms in
dapsone-induced severe cutaneous adverse reactions (SCAR). We investigated the …

Pharmacogenetic testing for prevention of severe cutaneous adverse drug reactions

CJ Chang, CB Chen, SI Hung, C Ji… - Frontiers in …, 2020 - frontiersin.org
… as severe cutaneous adverse drug reactions (SCAR). The immune mechanism of SCAR is
classified as type-IV hypersensitivity reaction … drugs and severe cutaneous adverse reactions (…

Severe cutaneous adverse reactions: the pharmacogenomics from research to clinical implementation

SC Su, SI Hung, WL Fan, RL Dao… - International Journal of …, 2016 - mdpi.com
Severe cutaneous adverse reactions (SCARs), previously thought to be idiosyncratic or
unpredictable, are a deadly form of adverse drug reactions with skin manifestations. Current …

Covalent binding of carbamazepine reactive metabolites to P450 isoforms present in the skin

P Wolkenstein, C Tan, S Lecoeur, J Wechsler… - Chemico-biological …, 1998 - Elsevier
… a high risk for severe cutaneous reactions. Upon metabolism by … a high risk of severe cutaneous
adverse reactions, especially … P450 2C9, 2C18 and 2E1 did not produce any detectable …