Associations between HLA class I and cytochrome P450 2C9 genetic polymorphisms and phenytoin-related severe cutaneous adverse reactions in a Thai population
W Tassaneeyakul, N Prabmeechai… - Pharmacogenetics …, 2016 - journals.lww.com
… of several types of severe cutaneous adverse reactions (SCAR) such as Stevens–Johnson
syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reactions with eosinophilia and …
syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reactions with eosinophilia and …
Genetic Determinants in HLA and Cytochrome P450 Genes in the Risk of Aromatic Antiepileptic-Induced Severe Cutaneous Adverse Reactions
AF Ahmed, C Sukasem, MA Sabbah, NF Musa… - Journal of Personalized …, 2021 - mdpi.com
… This has become apparent in the event of severe cutaneous adverse reactions (SCARs),
which can be life-threatening. In this review, four hypotheses were identified to describe how …
which can be life-threatening. In this review, four hypotheses were identified to describe how …
Genetic polymorphism of cytochrome P 450 2C9 in diphenylhydantoin-induced cutaneous adverse drug reactions
AY Lee, MJ Kim, WY Chey, J Choi, BG Kim - European journal of clinical …, 2004 - Springer
… for DPH-induced skin reactions. Therefore, … adverse reactions. However, the small sample
size in this study indicates that further studies on patients with DPH-induced skin reactions are …
size in this study indicates that further studies on patients with DPH-induced skin reactions are …
Association analysis of CYP2C9* 3 and phenytoin-induced severe cutaneous adverse reactions (SCARs) in Thai epilepsy children
S Suvichapanich, J Jittikoon, N Wichukchinda… - Journal of human …, 2015 - nature.com
… symptoms (DRESS) are considered Severe Cutaneous Adverse Reactions (SCARs). SJS …
:02, which has been strongly associated with serious skin reactions, in ancestry across broad …
:02, which has been strongly associated with serious skin reactions, in ancestry across broad …
Association of CYP 2C9* 3 with phenytoin‐induced Stevens‐Johnson syndrome and toxic epidermal necrolysis: A systematic review and meta‐analysis
X Wu, W Liu, W Zhou - Journal of Clinical Pharmacy and …, 2018 - Wiley Online Library
… included “cytochrome P450 2C9” OR “CYP2C9” AND “phenytoin” AND “Stevens-Johnson
syndrome” OR “toxic epidermal necrolysis” OR “severe cutaneous adverse reactions.” There …
syndrome” OR “toxic epidermal necrolysis” OR “severe cutaneous adverse reactions.” There …
Clinical consequences of cytochrome P450 2C9 polymorphisms
J Kirchheiner, J Brockmöller - Clinical Pharmacology & …, 2005 - Wiley Online Library
… with severe adverse events or greatly enhanced effects and … most severe cases of adverse
events or exaggerated effects … adverse effects will not be cost-effective unless the toxicity is …
events or exaggerated effects … adverse effects will not be cost-effective unless the toxicity is …
HLA-B*13 :01 Is a Predictive Marker of Dapsone-Induced Severe Cutaneous Adverse Reactions in Thai Patients
P Satapornpong, J Pratoomwun, P Rerknimitr… - Frontiers in …, 2021 - frontiersin.org
… However, studies have not highlighted the importance of other genetic polymorphisms in
dapsone-induced severe cutaneous adverse reactions (SCAR). We investigated the …
dapsone-induced severe cutaneous adverse reactions (SCAR). We investigated the …
Pharmacogenetic testing for prevention of severe cutaneous adverse drug reactions
… as severe cutaneous adverse drug reactions (SCAR). The immune mechanism of SCAR is
classified as type-IV hypersensitivity reaction … drugs and severe cutaneous adverse reactions (…
classified as type-IV hypersensitivity reaction … drugs and severe cutaneous adverse reactions (…
Severe cutaneous adverse reactions: the pharmacogenomics from research to clinical implementation
… Severe cutaneous adverse reactions (SCARs), previously thought to be idiosyncratic or
unpredictable, are a deadly form of adverse drug reactions with skin manifestations. Current …
unpredictable, are a deadly form of adverse drug reactions with skin manifestations. Current …
Covalent binding of carbamazepine reactive metabolites to P450 isoforms present in the skin
P Wolkenstein, C Tan, S Lecoeur, J Wechsler… - Chemico-biological …, 1998 - Elsevier
… a high risk for severe cutaneous reactions. Upon metabolism by … a high risk of severe cutaneous
adverse reactions, especially … P450 2C9, 2C18 and 2E1 did not produce any detectable …
adverse reactions, especially … P450 2C9, 2C18 and 2E1 did not produce any detectable …
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