… progressive stages of the disease. We propose that the inflammatory demyelinating disease
process in early multiple sclerosis … that treatment of progressive multiple sclerosis should be …

… Therefore, the half of patients with multiple sclerosis who have progressive disease have …
of how we can help patients with primary progressive multiple sclerosis (PPMS) and SPMS. …

… inflammatory process and pathogenetic mechanisms in multiple sclerosis (MS). … progressive
MS and discusses new data on the mechanisms underlying its pathogenesis. In progressive …

PMS represents a significant challenge, as the pathogenesis of the disease is not well
understood, no validated outcome metrics have been established, and clinical trial experience to …

About 10–15% of patients with multiple sclerosis (MS) present with gradually increasing
neurological disability, a disorder known as primary-progressive multiple sclerosis (PPMS). …

… Relapsing/remitting multiple sclerosis (RRMS) appears to be largely … progressive disease
(primary progressive multiple sclerosis, PPMS and secondary progressive multiple sclerosis, …

… may be key processes in progressive disease. Interfering with these … clinical trials in
progressive multiple sclerosis have yielded … involved in progressive multiple sclerosis, correlations …

… of secondary progressive multiple sclerosis has been lacking… definition for secondary
progressive multiple sclerosis, to … definitions for secondary progressive multiple sclerosis and first …

… progressive multiple sclerosis differ from those of the more common secondary progressive
… dysfunction, is significantly less in the primary progressive form, has led to the hypothesis …

… and risk factors for progression to and from secondary-progressive multiple sclerosis (SPMS). …
The clinical features and natural history of primary progressive multiple sclerosis . Brain …