… The chemical constrains imposed by the biological conditions cause significant challenges
… of the cleavable linkers used in chemical biology classified according to their cleavage …

… chemically cleavable linkers equipped with dialkoxydiphenylsilane (DADPS linker) and
azobenzene (AZO linker… the residual mass of the azobenzene linker. Furthermore, we conducted …

… linker. Through easy-to-handle chemistry we incorporate this linker into an activity-based …
a complex proteome is a major theme in chemical biology and proteomics. An effective method …

… internal cleavable linkers have been remodeled from the terminal decaging chemistry by …
expanding the boundary and utility of this powerful chemical biology toolkit. Finally, we hope to …

… A stable or cleavable linker connects the two modules of a … of chimeric molecules leveraging
chemical biology concepts. This … Other linkers used in chemical biology can be generated …

… currently employed for ADCs (involving cleavable linkers) are largely focused on native …
antibody-drug linker. To address these issues, a bioorthogonally cleavable linker could be …

… -cleavable linkers from various research areas and the corresponding mechanisms of linker
cleavage and biological … chemists, chemical biologist, nanomaterial scientists and biologist, …

… This review summarises the advances in the field of cleavable linker technologies for ADCs.
… of chemically cleavable linkers: acid cleavable, reducible disulfides and those cleavable by …

… Covalent chemical probes are important tools in chemical biology. They range from post-translational
modification (PTM)-derived metabolic probes, to activity-based probes and …

… Enzymatically cleavable linkers are particularly popular since the high intracellular abundance
of enzymes ensure specific release (Figure 1a). Also, some enzymes are overexpressed …