Background In vivo case reports and in vitro studies have indicated that aerosol therapy
using face masks can result in drug deposition on the face and in the eyes, and that face
mask design may affect drug delivery. Objective To test different mask/nebulizer
combinations for budesonide, a nebulized steroid used to treat pediatric patients with
asthma. Methods Using high-performance liquid chromatography, drug delivery (inhaled
mass), facial, and ocular deposition of budesonide aerosols were studied in vitro using a …