A large gene family in fission yeast encodes spore killers that subvert Mendel's law

W Hu, ZD Jiang, F Suo, JX Zheng, WZ He, LL Du - Elife, 2017 - elifesciences.org
… that there are at least two spore killer genes on chromosome III of CBS5557. To narrow
down the genomic regions containing the spore killer genes, we performed multiple rounds of …

Molecular mechanisms and evolutionary consequences of spore killers in ascomycetes

S Zanders, H Johannesson - Microbiology and Molecular Biology …, 2021 - Am Soc Microbiol
… the genes of the Spok gene family underlie the Psk spore killers (49), and the relationship
between the Spok gene family … two genes of the Spok gene family, Spok1 and Spok2, as novel …

The spore killers, fungal meiotic driver elements

AA Vogan, I Martinossi-Allibert, SL Ament-Velásquez… - Mycologia, 2022 - Taylor & Francis
… Although we currently only have two examples of spore killing gene family expansion, they
both suggest that the prevailing forces promote diversification into independent drivers, rather …

[HTML][HTML] Proliferation and dissemination of killer meiotic drive loci

EC Lai, AA Vogan - Current Opinion in Genetics & Development, 2023 - Elsevier
… represent true spore killer gene families, or recent co-option of domestic gene families requires
… These observations lead us to hypothesize that gene family expansion of killer meiotic …

Killer Meiotic Drive and Dynamic Evolution of the wtf Gene Family

MT Eickbush, JM Young… - Molecular Biology and …, 2019 - academic.oup.com
… of identified meiotic drive genes. Here, we analyze the evolution of the wtf gene family of
Schizosaccharomyces pombe that contains both killer meiotic drive genes and suppressors of …

On the mechanistic basis of killer meiotic drive in fungi

SJ Saupe, H Johannesson - Annual Review of Microbiology, 2022 - annualreviews.org
Spore killers are specific genetic elements in fungi that kill … The gene family was poorly
characterized, but several … of the wtf gene family act as autonomous spore-killing elements, …

A natural fungal gene drive enacts killing via DNA disruption

AS Urquhart, DM Gardiner - Mbio, 2023 - Am Soc Microbiol
spore killer protein Spok1, which has homologues throughout the fungal tree of life, acts via
DNA disruption. Spok1 is only the second spore killer … will be conserved in this gene family. …

Fungal ribotoxins: molecular dissection of a family of natural killers

J Lacadena, E Álvarez-García… - FEMS microbiology …, 2007 - academic.oup.com
… RNase T1 is the best known representative of a large family of ribonucleolytic proteins …
within a universally conserved sequence of the large rRNA gene, known as the sarcin–ricin loop. …

Genetic villains: killer meiotic drivers

MAB Núñez, NL Nuckolls, SE Zanders - Trends in genetics, 2018 - cell.com
… An imbalance of Slx and Sly copy numbers in hybrids or knockdown of either gene family
the phenotypes of mutants in which the gamete (or spore)-specific component is absent. In …

A family of killers

M De Carvalho, SE Zanders - Elife, 2019 - elifesciences.org
… two new Spok genes (Spok3 and Spok4) that are both spore killers. … gene family underlies
the Psks. The combination of Spok genes at different chromosomal locations defines the spore