… and in peripheral opioid-mediated antinociception was … sensory neurons, we demonstrated
that antinociception to a … that peripheral endogenous opioid-mediated antinociception in late …

… Here we investigated the contribution of peripheral monocyte/macrophages in regulating …
In addition, we investigated the role of peripheral macrophages/monocytes and the anti-…

… The present study examines molecular mechanisms of peripheral opioid-mediated …
antinociception and iii) involvement of TLR4 in the generation of tonic peripheral antinociception. …

… By understanding the role of IGF1, APOE, and the context required for the emergence of
antinociceptive microglia, new therapeutic strategies can be designed to promote analgesia and …

… It has been demonstrated that peripheral inflammatory pain can be effectively controlled by
an … in peripheral inflammatory conditions and the clinical implications of targeting peripheral …

IL-4 is a pleiotropic antiinflammatory cytokine, which can be neuroprotective after nervous
system injury. The beneficial actions of IL-4 are thought to result from the blunting of action of …

… pain in humans, whereas in animals, the term “antinociception” is used to define the inhibition
of … , and “analgesia” is used for both analgesia in humans and antinociception in animals. …

Background: Macrophage infiltration to inflammatory sites promotes wound repair and may
be involved in pain hypersensitivity after surgical incision. We recently reported that the …

… This conclusion is supported by the observation that the peripheral antinociceptive activity
of 15d-PGJ 2 was prevented by inhibitors of NOS, cGMP, and PKG. The analgesic activity of …

… , resulting in negligible peripheral antinociception (1). Therefore, the release of opioid peptides
from immune cells in close apposition to peripheral sensory neurons would maximize the …