Cytosine methylation is an epigenetically propagated DNA modification that can modify how
the DNA molecule is recognized and expressed. DNA methylation undergoes extensive
reprogramming during mammalian embryogenesis and is directly linked to the regulation of
pluripotency and cellular identity. Studying its regulation is also important for a better
understanding of the many diseases that show epigenetic deregulations, in particular,
cancer. In the recent years, a lot of progress has been made to characterize the profiles of …

DNA methylation, the addition of a methyl group at the 5-position of cytosine (5-
methylcytosine, 5mC), is a major epigenetic modification in the genomes of many animals,
plants, and fungi. In mammals, DNA methylation is involved in a variety of biological
processes. Generally considered a stable chromatin mark, DNA methylation exhibits
dynamic changes during mammalian development, including early embryogenesis and
germ cell development. These changes are mediated by DNA methylation and …