… to inhibit pain within inflamed tissue. This study examined μ-opioid receptors (MOR) on …
+ cells (the predominant population homing to inflamed tissue). We found an upregulation of …

… Peripheral inflammation results in the production of multiple chemical mediators that
originate from tissue … Regulation of µ-opioid receptor gene transcription by interleukin-4 and …

… Injury and inflammation of peripheral tissues leads to increased synthesis, axonal transport,
… tolerance at peripheral μ-opioid receptors in the presence of painful paw inflammation. In …

… Thus they may also play a role in intrinsic mechanisms of opioid antinociception in inflamed
tissue. Although a bewildering number of different cytokines are currently recognized, their …

… whether inflammation in the orofacial muscle alters μ opioid … to assess the contribution of
peripheral MORs under acute and … The increase in peripheral opioid efficacy in inflamed tissue …

… The selective µ-opioid antagonist CTOP as well as the selective δ-opioid antagonist
naltrindole dose-dependently inhibited both noradrenaline- and isoprenaline-induced …

… an immediate role in our model of inflamed paw tissue. Another possible mechanism has …
, 1995): inflammation produces a disruption of the perineural barrier around peripheral sensory …

… peripheral sensory nerve endings. At the same time, immune cells containing endogenous
opioid peptides accumulate within the inflamed tissue. … those containing µ opioid receptors at …

… The opioid receptors on peripheral sensory nerves are up-regulated during inflammation. …
by the resident immune cells in inflamed peripheral tissue. Environmental stimuli and …

… and inflammation) and at least four different tissue sections … of synaptophysin in control and
inflamed tissues (Fig. 4, C and D, … of μ-OR in a peripheral tissue. Our results differ from those …